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WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish [zebrafish RNAseq]

ABSTRACT: WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish [zebrafish RNAseq]

PROVIDER: PRJNA737628 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14813038_1.fastq.gz	Fastqsanger.gz
	SRR14813038_2.fastq.gz	Fastqsanger.gz
	SRR14813039_1.fastq.gz	Fastqsanger.gz
	SRR14813039_2.fastq.gz	Fastqsanger.gz
	SRR14813040_1.fastq.gz	Fastqsanger.gz

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WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish [zebrafish RNAseq]

Project description:Granulomas are the pathological hallmark of tuberculosis (TB). In individuals latently infected with Mycobacterium tuberculosis (M. tb), the bacteria are thought to reside within the granulomas in a nonreplicating dormant state due to the lack of oxygen and nutrients. However, a portion of these individuals will develop active TB and little is known on the bacterial mechanisms/factors involved in this process. In this study, we found that WhiB4, an oxygen sensor and a transcription factor, plays a critical role in disease progression and reactivation of Mycobacterium marinum (M. marinum) infection in zebrafish. We show that the whiB4 mutant of M. marinum caused latent infection in adult zebrafish, which is characterized by the stable bacterial loads, constant number of non-necrotized granulomas in fewer organs, and reduced immune responses compared to zebrafish infected with the wild type bacteria or the complemented strain. The mutant bacteria in zebrafish were also less responsive to antibiotic treatments. Moreover, the whiB4 mutant was defective in resuscitation from hypoxia-induced dormancy and that the DosR regulon was dysregulated in the mutant. Taken together, our results suggest that WhiB4 is a major driver of reactivation from latent infection and that WhiB4 is an attractive target for the development of novel therapeutics, which may help to prevent the reactivation of latent infection thereby reducing the incidences of active TB.

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WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish II

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WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish [ChIP-Seq]

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WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish [bacteria RNA seq]

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WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish

Project description:WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish

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WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish II

Project description:WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish II

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WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish [ChIP-Seq]

Project description:WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish [ChIP-Seq]

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WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish [bacteria RNA seq]

Project description:WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish [bacteria RNA seq]

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A microarray to characterize the immune response of adult zebrafish to a low dose Mycobacterium marinum infection

Project description:Zebrafish Mycobacterium marinum infection has been widely used to model human tuberculosis because these two diseases share common features, e.g. latency, granuloma formation and reactivation. Here we infected adult zebrafish with a low dose of M. marinum, which usually leads to a chronic infection. At 14 days post infection we performed microarray analysis to characterize the immune response against this infection. Analysis was done using total RNA extracted from the abdominal organs of zebrafish. Our aim was to find novel genes underlying host defense mechanisms against M. marinum infection in zebrafish, and thus to produce novel information that is valuable when developing new treatments for human tuberculosis.

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WhiB4 is required for the reactivation of latent infection of Mycobacterium marinum in zebrafish

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-16 | GSE178191 | GEO