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Efffect of a high fructose diet on miRNA expression in vervet monkey livers

ABSTRACT: Efffect of a high fructose diet on miRNA expression in vervet monkey livers

PROVIDER: PRJNA738169 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14821252.fastq.gz	Fastqsanger.gz
	SRR14821253.fastq.gz	Fastqsanger.gz
	SRR14821254.fastq.gz	Fastqsanger.gz
	SRR14821255.fastq.gz	Fastqsanger.gz
	SRR14821256.fastq.gz	Fastqsanger.gz

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Efffect of a high fructose diet on miRNA expression in vervet monkey livers

Project description:High-throughput profiling of miRNA expression in the livers of vervet monkeys fed a high fructose or chow diet. Analysis of differentially expressed miRNAs revealed miR-148a-3p, miR-181a-5p, miR-342-5p and miR-574-5p may have regulatory roles in coordinating changes in hepatic gene expression in response to a high fructose diet.

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Efffect of a high fructose diet on gene expression in vervet monkey livers.

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Efffect of a high fructose diet on gene expression in vervet monkey livers.

Project description:Efffect of a high fructose diet on gene expression in vervet monkey livers.

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Project description:This report is based on an ongoing study to examine gene expression differences in monkey lateral geniculate nucleus (LGN). For this study, samples from an Old World species, vervet monkey (Cercopithecus aethiops), were cross-hybridized to the Rhesus Macaque Genome Array (Affymetrix). Microarray analysis was performed using laser capture microdissected populations of individual neuronal cell bodies isolated from the LGN compared to heterogeneous samples from whole lamina. We show here that cross-species hybridization of microdissected brain tissue samples from vervet monkeys to the Rhesus array produced reliable and biologically relevant data sets. We present the first list of genes enriched in the large neuronal cell bodies of the LGN. We found that these cell bodies are concentrated with genes involved in metabolic processes and protein synthesis, whereas signaling molecules including chemokines and integrins were expressed at higher levels within heterogeneous samples. Our data set provides support for a contribution of Wnt signaling in adult monkey LGN. Keywords: gene expression profile

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Project description:DNA methylation data from vervet cerebral cortex, blood, and liver using highly conserved mammalian CpGs represented on the mammalian methylation array (HorvathMammalMethylChip40). We selected a total of 240 samples representing the entire vervet lifespan, from neonatal to senile stages: 144 samples from the peripheral blood, 48 samples from the liver, and 48 samples from the cortical brain area BA10.

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