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Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon

ABSTRACT: Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon

PROVIDER: PRJNA739103 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14861435_1.fastq.gz	Fastqsanger.gz
	SRR14861435_2.fastq.gz	Fastqsanger.gz
	SRR14861436_1.fastq.gz	Fastqsanger.gz
	SRR14861436_2.fastq.gz	Fastqsanger.gz
	SRR14861437_1.fastq.gz	Fastqsanger.gz

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Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon [Array]

Project description:The strength of the T cell receptor interaction with self-ligands affects antigen-specific immune responses. However, the precise role, functional relationship, and underlying mechanisms have not been elucidated completely. Here, we demonstrate that naive CD8+ T cells with relatively high self-reactivity are phenotypically heterogeneous owing to varied responses to type I interferon (T1IFN), resulting in three distinct subsets, CD5loLy6C–, CD5hiLy6C–, and CD5hiLy6C+ cells. CD5hiLy6C+ cells differ from CD5loLy6C– and CD5hiLy6C– cells in their gene expression profiles and functional properties. Moreover, CD5hiLy6C+ cells demonstrate more extensive antigen-specific expansion upon viral infection, with enhanced differentiation into terminal effector cells and reduced memory cell generation. Such unique features of CD5hiLy6C+ cells are imprinted in a steady-state and observed even for those of monoclonal CD8+ T cell populations in a T1IFN dependent fashion. These findings demonstrate that self-reactivity shapes the functional diversity of naive CD8+ T cells by co-opting tonic T1IFN signaling.

2021-06-19 | GSE178445 | GEO

Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon [RNA-Seq_2]

2021-06-19 | GSE178448 | GEO

Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon [RNA-Seq_1]

2021-06-19 | GSE178447 | GEO

Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon [Array]

Project description:Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon [Array]

| PRJNA739107 | ENA

Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon [RNA-Seq_1]

Project description:Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon [RNA-Seq_1]

| PRJNA739108 | ENA

Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon [RNA-Seq_2]

Project description:Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon [RNA-Seq_2]

| PRJNA739109 | ENA

Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-19 | GSE178449 | GEO

Developmental self-reactivity determines the pathogenic Tc17 differentiation potential of naive CD8+ T cells by adjusting endogenous SMAD3 expression

Project description:The differentiation of naive CD8+ T cells into effector cells is important for establishing immunity. However, the effect of heterogeneous naive CD8+ T cell populations is not fully understood. Here, we demonstrate that steady-state naive CD8+ T cells are composed of functionally heterogeneous subpopulations that differ in their ability to differentiate into type 17 cytotoxic effector cells (Tc17) in inflammatory disease models. The differential ability of Tc17 differentiation was not related to T-cell receptor (TCR) diversity and antigen specificity but was inversely correlated with self-reactivity acquired during development. Mechanistically, this phenomenon was linked to differential levels of intrinsic TCR sensitivity and basal SMAD3 expression, generating a wide spectrum of Tc17 differentiation potential within naive CD8+ T cell populations. These findings suggest that developmental self-reactivity can determine the fate of naive CD8+ T cells to generate functionally distinct effector populations and achieve immense diversity and complexity in antigen-specific T-cell immune responses.

2023-08-15 | GSE240440 | GEO

Self-reactivity controls functional diversity of naive CD8<sup>+</sup> T cells by co-opting tonic type I interferon.

Project description:The strength of the T cell receptor interaction with self-ligands affects antigen-specific immune responses. However, the precise function and underlying mechanisms are unclear. Here, we demonstrate that naive CD8+ T cells with relatively high self-reactivity are phenotypically heterogeneous owing to varied responses to type I interferon, resulting in three distinct subsets, CD5loLy6C-, CD5hiLy6C-, and CD5hiLy6C+ cells. CD5hiLy6C+ cells differ from CD5loLy6C- and CD5hiLy6C- cells in terms of gene expression profiles and functional properties. Moreover, CD5hiLy6C+ cells demonstrate more extensive antigen-specific expansion upon viral infection, with enhanced differentiation into terminal effector cells and reduced memory cell generation. Such features of CD5hiLy6C+ cells are imprinted in a steady-state and type I interferon dependence is observed even for monoclonal CD8+ T cell populations. These findings demonstrate that self-reactivity controls the functional diversity of naive CD8+ T cells by co-opting tonic type I interferon signaling.

| S-EPMC8523551 | biostudies-literature

DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency

Project description:To formally assess how 5mC shapes the H3K27me3 landscape, we profiled the epigenome of naive and differentiated cells in the presence and absence of the DNA methylation machinery.

2024-07-16 | GSE242201 | GEO

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