Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: The single nucleotide polymorphisms of NOD2 genes in CD patients

PROVIDER: PRJNA739398 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14866700.fastq.gz	Fastqsanger.gz
	SRR14866701.fastq.gz	Fastqsanger.gz
	SRR14866602.fastq.gz	Fastqsanger.gz
	SRR14866702.fastq.gz	Fastqsanger.gz
	SRR14866603.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 125

Similar Datasets

Impact of NOD2 Genotype on the Innate Monocyte Transcriptome in Crohn’s Disease

Project description:Short title: Innate Gene/miRNA MDP-response in CD RNA-seq and small RNA-seq were used to identify the expression of gene and microRNA (miRNA) in monocytes from healthy controls and patients with Crohn's Disease (CD), with and without NOD2 (nucleotide-binding oligomerization domain-containing protein 2) single nucleotide polymorphisms (SNPs) after stimulation with muramyl dipeptide (MDP).

2017-02-15 | GSE69446 | GEO

Immune-restricted epigenetic reader SP140 maintains macrophage identity and activation states critical to intestinal homeostasis [ATAC-Seq]

Project description:Introduction: SP140 is a bromodomain/plant homeo domain (PHD)-containing reader with immune-restricted expression, and single nucleotide polymorphisms (SNPs) within SP140 associate with Crohn’s disease (CD). However, the function of SP140 and the consequences of disease-associated SP140 SNPs have remained unknown. Results: Individuals carrying CD-associated SNPs within SP140 had defective SP140 mRNA splicing, diminished SP140 protein, and severely suppressed innate immune signatures that stratified them from other CD patients. Conclusion: SP140 is a critical orchestrator of macrophage identity, and a loss of SP140 due to genetic variation contributes to a molecularly defined subset of CD characterized by suppressed innate immunity.

2017-05-03 | GSE89177 | GEO

Immune-restricted epigenetic reader SP140 maintains macrophage identity and activation states critical to intestinal homeostasis [ChIP-seq]

2017-05-03 | GSE90126 | GEO

Immune-restricted epigenetic reader SP140 maintains macrophage identity and activation states critical to intestinal homeostasis [array]

2017-05-03 | GSE89870 | GEO

Immune-restricted epigenetic reader SP140 maintains macrophage identity and activation states critical to intestinal homeostasis [RNA-seq]

2017-05-03 | GSE83381 | GEO

Myeloid-stromal subtypes reveal NOD2-mediated Crohn's and rescue pathways

Project description:Crohn’s disease (CD) is a chronic inflammatory intestinal disease, often characterized by aberrant healing and stricturing complications. Mechanisms underlying NOD2-pathogenicity and salvage pathways in anti-TNF and refractory patients remain largely uncharacterized. Here we show that loss of NOD2 function leads to aberrant activated fibroblast and macrophage homeostasis through the upregulation of a pathogenic signature, and propose new precision therapeutic approaches involving gp130 blockade for select CD patients, to potentially supplement anti-TNF therapy

2021-03-05 | GSE150498 | GEO

Changes of Muramyl Dipeptide in Intestinal and Extra-intestinal Diseases

Project description:Nucleotide-binding oligomerization domain 2 (Nod2) signaling is critical for human health.To figure out the clinical relevance of NOD2 ligands, the investigators plan to evaluate the change of NOD2 ligands in inflammatory bowel diseases (IBD), CRC, atherosclerotic cardiovascular disease (ACVD), and type 2 diabetes mellitus (DM2 ).

| 2380440 | ecrin-mdr-crc

Homo sapiens

Project description:Single-nucleotide polymorphisms and TTV

| PRJNA898147 | ENA

The impact of a drug transporter ABCG2 haplotype in molecular response of chronic myelogenous leukemia patients is modulated by imatinib dose

Project description:We analysed the impact of single nucleotide polymorphisms (SNPs) in drug transporter genes on the molecular response to imatinib, using 857 SNPs covering 94 drug transporter genes on 355 chronic phase chronic myeloid leukemia (CP-CML) patients.

2014-06-30 | GSE52107 | GEO

Exploratory research to investigate the single nucleotide polymorphisms (SNP) which can predict oxaliplatin-induced neuropathy

Project description:Primary outcome(s): To investigate the single nucleotide polymorphisms correlated with oxaliplatin-induced neuropathy

| 2616724 | ecrin-mdr-crc