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Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle.

ABSTRACT: Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle.

PROVIDER: PRJNA739496 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14868304_1.fastq.gz	Fastqsanger.gz
	SRR14868304_2.fastq.gz	Fastqsanger.gz
	SRR14868305_1.fastq.gz	Fastqsanger.gz
	SRR14868305_2.fastq.gz	Fastqsanger.gz
	SRR14868306_1.fastq.gz	Fastqsanger.gz

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Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [RNA-seq]

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Project description:Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [scATAC-seq]

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Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [scRNA-seq]

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Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [ChIP-seq]

Project description:Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [ChIP-seq]

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Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [scRNA-seq]

Project description:Cell cycle (CC) is a fundamental biological process with robust, cyclical gene expression programs to facilitate cell division. In the immune system, a productive immune response requires the expansion of pathogen-responsive cell types, but whether CC also confers unique gene expression programs that inform the subsequent immunological response remains unclear. Here we demonstrate that single macrophages adopt different plasticity states in CC which is a major source of heterogeneity in response to polarizing cytokines. Specifically, macrophage plasticity to interferon gamma (IFNG) is substantially reduced, while interleukin 4 (IL-4) can induce S-G2/M-biased gene expression. Additionally, IL-4 polarization shifts the CC-phase distribution of the population towards G2/M phase, providing a mechanism for reduced IFNG-induced repolarization. Finally, we show that macrophages express tissue remodeling genes in the S-G2/M-phases of CC, that can be also detected in vivo during muscle regeneration. Therefore, CC defines macrophage inflammatory and regenerative responses in a cyclical, CC-phase-dependent manner.

2021-10-01 | GSE178525 | GEO

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [ChIP-seq]

2021-10-01 | GSE178522 | GEO

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [scATAC-seq]

2021-10-01 | GSE178524 | GEO

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle [RNA-seq]

2021-10-01 | GSE178523 | GEO

Cyclical macrophage plasticity provides periodic inflammatory and regenerative gene expression programs in cell cycle.

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-10-01 | GSE178526 | GEO

The effects of periodic restricted feeding on Rhesus Macaques

Project description:Dietary restriction has shown benefits in physiological, metabolic, and molecular signatures associated with aging. In mice, periodic dietary restriction, that accompanies cyclical periods of reduced calories, mitigates aging phenotypes, yet the effects of this periodic restriction in higher order, genetically heterogenous mammals, have not been investigated. Reducing caloric intake in middle-aged Rhesus Macaques for four days followed by ad libitum eating for ten days, repeated for six cycles, led to significant changes in body composition, metabolome, and microbiome of the restricted monkeys compared to their ad libitum fed (age and sex matched) controls. These changes were also associated with stabilized blood parameters. The changes in metabolome, microbiome, and body compositions were additive, with consistent but increasingly pronounced changes in later cycles, suggesting sustaining benefits in non-human primates. These results suggest this type of cyclical dietary restriction, that is easy to adhere to, will also have translational benefits in humans while enhancing aging-associated parameters.

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