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Epigenetic Regulation of Nuclear Lamina-Associated Heterochromatin by HAT1 and the Acetylation of Newly Synthesized Histones

ABSTRACT: Epigenetic Regulation of Nuclear Lamina-Associated Heterochromatin by HAT1 and the Acetylation of Newly Synthesized Histones

PROVIDER: PRJNA739696 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14871818_1.fastq.gz	Fastqsanger.gz
	SRR14871818_2.fastq.gz	Fastqsanger.gz
	SRR14871819_1.fastq.gz	Fastqsanger.gz
	SRR14871819_2.fastq.gz	Fastqsanger.gz
	SRR14871820_1.fastq.gz	Fastqsanger.gz

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Project description:We report that HAT1 regulates chromatin accessibility of large chromosomal domains.

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Epigenetic Regulation of Nuclear Lamina-Associated Heterochromatin by HAT1 and the Acetylation of Newly Synthesized Histones [pMEF_RNA_Seq]

Project description:We report that HAT1 regulates chromatin accessibility of large chromosomal domains. We also report that changes in chromatin accessibility are not strictly correlated to changes in transcription.

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Epigenetic Regulation of Nuclear Lamina-Associated Heterochromatin by HAT1 and the Acetylation of Newly Synthesized Histones [ChIP-seq]

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Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones.

Project description:A central component of the epigenome is the pattern of histone post-translational modifications that play a critical role in the formation of specific chromatin states. Following DNA replication, nascent chromatin is a 1:1 mixture of parental and newly synthesized histones and the transfer of modification patterns from parental histones to new histones is a fundamental step in epigenetic inheritance. Here we report that loss of HAT1, which acetylates lysines 5 and 12 of newly synthesized histone H4 during replication-coupled chromatin assembly, results in the loss of accessibility of large domains of heterochromatin, termed HAT1-dependent Accessibility Domains (HADs). HADs are mega base-scale domains that comprise ∼10% of the mouse genome. HAT1 globally represses H3 K9 me3 levels and HADs correspond to the regions of the genome that display HAT1-dependent increases in H3 K9me3 peak density. HADs display a high degree of overlap with a subset of Lamin-Associated Domains (LADs). HAT1 is required to maintain nuclear structure and integrity. These results indicate that HAT1 and the acetylation of newly synthesized histones may be critical regulators of the epigenetic inheritance of heterochromatin and suggest a new mechanism for the epigenetic regulation of nuclear lamina-heterochromatin interactions.

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Old and newly synthesized histones are asymmetrically distributed in Drosophila intestinal stem cell divisions

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