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A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells

ABSTRACT: A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells

PROVIDER: PRJNA739891 | ENA |

REPOSITORIES: ENA

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A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells

Project description:The transcription factors STAT5A and STAT5B are critical in hematopoiesis and leukemia. They are widely believed to have redundant functions but we describe a unique role for STAT5B in driving the self-renewal of hematopoietic and leukemic stem cells (HSCs/LSCs). We find STAT5B to be specifically activated in HSCs and LSCs, where it induces many genes associated with quiescence and self-renewal, including the surface marker CD9. Levels of CD9 represent a prognostic marker for patients with STAT5-driven leukemia and our findings suggest that anti-CD9 antibodies may be useful in their treatment to target and eliminate LSCs. We show that it is vital to consider STAT5A and STAT5B as distinct entities in normal and malignant hematopoiesis.

2021-12-31 | GSE178648 | GEO

A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells.

Project description:The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B are critical in hematopoiesis and leukemia. They are widely believed to have redundant functions, but we describe a unique role for STAT5B in driving the self-renewal of hematopoietic and leukemic stem cells (HSCs/LSCs). We find STAT5B to be specifically activated in HSCs and LSCs, where it induces many genes associated with quiescence and self-renewal, including the surface marker CD9. Levels of CD9 represent a prognostic marker for patients with STAT5-driven leukemia, and our findings suggest that anti-CD9 antibodies may be useful in their treatment to target and eliminate LSCs. We show that it is vital to consider STAT5A and STAT5B as distinct entities in normal and malignant hematopoiesis.

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Cd9

Project description:Rattus norvegicus Cd9, CD9 molecule [Source:RGD Symbol;Acc:2318], is differentially expressed in 31 experiment(s);

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Cd9

Project description:Rattus norvegicus Cd9, CD9 molecule [Source:RGD Symbol;Acc:2318], is expressed in 9 baseline experiment(s);

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CD9

Project description:Sus scrofa CD9, CD9 molecule [Source:VGNC Symbol;Acc:VGNC:103224], is differentially expressed in 4 experiment(s);

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cd9

Project description:Xenopus tropicalis cd9, CD9 protein [Source:Xenbase;Acc:XB-GENE-949525], is differentially expressed in 1 experiment(s);

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