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Neuronal mimicry mechanisms promote the growth of small-cell lung cancer in the brain [human astrocytes RNA-seq]

ABSTRACT: Neuronal mimicry mechanisms promote the growth of small-cell lung cancer in the brain [human astrocytes RNA-seq]

PROVIDER: PRJNA740253 | ENA |

REPOSITORIES: ENA

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Neuronal mimicry mechanisms promote the growth of small-cell lung cancer in the brain [human astrocytes RNA-seq]

Project description:Small cell lung cancer (SCLC) is a fatal form of cancer that frequently metastasizes to the brain. Here we investigated the mechanisms allowing SCLC cells to grow in the unique brain microenvironment. We found that neuronal programs upregulated in SCLC cells during tumor progression and upon growth in the brain are critical for SCLC growth in the brain. Mechanistically, the presence of SCLC cells in the brain re-activates astrocytes, which in turn promote the survival of SCLC cells by secreting neuronal pro-survival factors such as SERPINE1. We also identified Reelin, a molecule produced by developing neurons to recruit astrocytes, as a molecule secreted by SCLC cells to recruit astrocytes to the tumor site and promote SCLC growth in the brain. Thus, SCLC cells co-opt mechanisms normally at play between astrocytes and neurons to promote SCLC growth in the brain. Targeting such developmental neuronal programs may help treat brain metastases.

2023-08-09 | GSE178738 | GEO

Neuronal mimicry mechanisms promote the growth small-cell lung cancer in the brain

2023-06-22 | GSE179032 | GEO

Neuronal mimicry mechanisms promote the growth of small-cell lung cancer in the brain [human SCLC cell RNA seq]

2023-08-09 | GSE178736 | GEO

Neuronal mimicry mechanisms promote the growth of small-cell lung cancer in the brain [TA and CA RNA-seq]

2023-08-09 | GSE178732 | GEO

Neuronal mimicry mechanisms promote the growth small-cell lung cancer in the brain

Project description:Neuronal mimicry mechanisms promote the growth small-cell lung cancer in the brain

| PRJNA741987 | ENA

Neuronal mimicry mechanisms promote the growth of small-cell lung cancer in the brain

Project description:Neuronal mimicry mechanisms promote the growth of small-cell lung cancer in the brain

| PRJNA740266 | ENA

Neuronal mimicry mechanisms promote the growth of small-cell lung cancer in the brain [human SCLC cell RNA seq]

Project description:Neuronal mimicry mechanisms promote the growth of small-cell lung cancer in the brain [human SCLC cell RNA seq]

| PRJNA740251 | ENA

Neuronal mimicry mechanisms promote the growth of small-cell lung cancer in the brain [TA and CA RNA-seq]

Project description:Neuronal mimicry mechanisms promote the growth of small-cell lung cancer in the brain [TA and CA RNA-seq]

| PRJNA740250 | ENA

MAFG-driven astrocytes promote CNS inflammation

Project description:MAFG-driven astrocytes promote CNS inflammation

| PRJNA534022 | ENA

Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules

Project description:Astrocytes, due to the proximity to neuronal lineage and capability to proliferate, are ideal starting cells to regenerate neurons. Human fetal astrocytes have been successfully converted into neuronal cells by small molecules, which offer a broader range of further applications than transcription factor-mediated neuronal reprogramming. Here we report human adult astrocytes could also be converted into neuronal cells by a different set with fewer small molecules. These induced neuronal cells exhibited typical neuronal morphologies, expressed neuronal markers, and displayed neuronal electrophysiological properties. Genome-wide RNA-sequencing analysis showed the gene expression profile of induced neuronal cells resembled that of human embryonic stem cell-differentiated neurons. When transplanted into postnatal mouse brains, these induced neuronal cells could survive in vivo. Altogether, our study provides a new strategy to directly generate transgene-free neurons from human adult astrocytes by small molecules.

2017-06-12 | GSE84826 | GEO

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