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Gut microbiota and metabolites analysis in serum

ABSTRACT: Gut-microbiota-brain axis involves in the neuroprotection of phosphoglycerate mutase 5 deficiency in traumatic brain injury mice

PROVIDER: PRJNA741415 | ENA |

REPOSITORIES: ENA

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gut microbiota and metabolites analysis in serum

Project description:Gut-microbiota-brain axis involves in the neuroprotection of phosphoglycerate mutase 5 deficiency in traumatic brain injury mice

| PRJNA973850 | ENA

Sumoylation-deficient phosphoglycerate mutase 2 impairs myogenic differentiation

Project description:Sumoylation-deficient phosphoglycerate mutase 2 impairs myogenic differentiation

| PRJNA909295 | ENA

Comparative proteomic analysis for a putative 2, 3-bisphosphoglycerate-dependent phosphoglycerate mutase in Acidovorax citrulli

Project description:- Identification of proteins whose expression was affected by a putative 2, 3-bisphosphoglycerate-dependent phosphoglycerate mutase in Acidovorax citrulli str. KACC17005 - Shotgun proteomic analysis was used - Two strains were used with three biological replicates (total 6 samples). WT: the wild-type strain. 2H: 2, 3-bisphosphoglycerate-dependent phosphoglycerate mutase knockout mutant

2022-10-24 | PXD035156 | Pride

Saccharomyces cerevisiae

Project description:Phosphoglycerate mutase knock-out mutant Saccharomyces cerevisiae: physiological investigation and transcriptome analysis

| PRJNA127587 | ENA

Project description:Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice

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NanoString analysis of mouse brain endothelial cells in response to peripheral LPS treatment.

Project description:Four daily intraperitoneal injections of the Gram-negative bacterial endotoxin lipopolysaccharide (LPS) transiently protects the cerebral cortex against traumatic brain injury. Underlying mechanisms associated with this neuroprotection include increased neuronal production of anti-apoptotic and neurotrophic molecules, microglial-mediated displacement of inhibitory presynaptic terminals innervating the soma of cortical projection neurons, and synchronized firing of cortical projection neurons. The molecular mechanisms responsible for inducing this neuroprotection and microglial activation are unknown. A fundamental question is whether LPS enters the central nervous system (CNS) or mediates it actions on the luminal surface of brain endothelial cells. In this study, we demonstrate that LPS injected into the peritoneum does not enter the CNS or alter tight junctions of brain endothelial cells. However, LPS activation of vascular endothelial cells was substantiated by increased expression of activation markers (CD54 and CD105) and the LPS receptor, TLR4, on CD31-positive brain endothelial cells isolated by flow cytometry. Transcript analyses further revealed significant upregulation of Cxcl10, C3, Ccl2, Il1b, Cxcl2, and Cxcl1 in these activated endothelial cells, consistent with identification of MyD88 as a regulator of these transcripts by pathway analysis. Using conditional brain endothelial gene ablation strategies, we establish that MyD88-dependent endothelial TLR4 signaling and endothelial Cxcl10 expression are essential for LPS-induced neuroprotection and microglial activation. CXCL10 production by brain endothelial cells in response to circulating TLR ligands thus provides a pathway to directly or indirectly signal to CXCR3 on neurons and/or microglia. Targeting activation of brain endothelial receptors provides an attractive and practical approach for inducing transient neuroprotection.

2022-02-01 | GSE193015 | GEO

Rattus norvegicus

Project description:Traumatic brain injury

| PRJNA1065340 | ENA

Etiology matters - Comparing Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy (TBI – MBD-seq)

Project description:Explore DNA methylation in traumatic brain injury model of epilepsy and its relationship to gene expression. Examination of methylation changes in stimulated rats compared to sham operated animals in traumatic brain injury model of epilepsy.

2016-09-06 | E-GEOD-75119 | biostudies-arrayexpress

Etiology matters - Comparing Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy (TBI â mRNA-seq)

Project description:Explore DNA methylation in traumatic brain injury model of epilepsy and its relationship to gene expression. Examination of expression changes in stimulated rats compared to sham operated animals in traumatic brain injury model of epilepsy.

2016-09-06 | E-GEOD-75120 | biostudies-arrayexpress

Potential blood biomarkers for chronic traumatic encephalopathy: the multi-omics landscape of an observational cohort (serum exosomes miRNA microarray data)

Project description:Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts, which is susceptible in elderly people with declined mobility, athletes of full contact sports, military personnel and victims of domestic violence. It has been pathologically diagnosed in brain donors with a history of repetitive mild traumatic brain injury (rmTBI), but cannot be clinically diagnosed for a long time. By the continuous efforts by neuropathologists, neurologists and neuroscientists in recent 10 years, an expert consensus for the diagnostic framework of CTE was proposed in 2021 funded by the National Institute of Neurological Disorders and Stroke. The new consensus contributes to facilitating research in the field. However, it still needs to incorporate in-vivo biomarkers to further refine and validate the clinical diagnostic criteria. From this, a single-center, observational cohort study has been being conducted by Tianjin Medical University General Hospital since 2021. As a pilot study of this clinical trial, the present research recruited 4 pairs of gender- and age-matched rmTBI patients with healthy subjects. Their blood samples were collected for exosome isolation, and multi-omics screening to explore potential diagnostic biomarkers in blood and its exosomes.

2022-10-18 | E-MTAB-12329 | biostudies-arrayexpress

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