Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation

ABSTRACT: Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation

PROVIDER: PRJNA742424 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation

Project description:Using a newly generated enzalutamide-resistant prostate cancer model, we characterized alterations in the translatome during prostate cancer enzalutamide resistance acquisition. We show a discordance between the translatome and transcriptome of drug-resistant cells, a deregulation of proteins involved in translation and an overall decrease in translational efficiency upon resistance acquisition. Interestingly, long non-coding RNAs show higher translation efficiency in enzalutamide-resistant cells, and a strong correlation with poor patient prognosis. Taken together, this suggests that aberrant translation of coding and non-coding genes are strong indicators of PCa enzalutamide-resistance.

2022-10-07 | GSE179157 | GEO

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

Project description:Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

| PRJNA601126 | ENA

Epidermal overexpression of ∆NLef1 leads to deregulation of epidermal stem cell fate

Project description:Epidermal overexpression of ∆NLef1 leads to deregulation of epidermal stem cell fate

| PRJNA484336 | ENA

Endothelial-specific mitochondiral complex III KO leads to lung endothelial cell gene deregulation.

Project description:Endothelial-specific mitochondiral complex III KO leads to lung endothelial cell gene deregulation.

| PRJNA498407 | ENA

Gene expression of conventional and unconventional T cell subsets

Project description:The experiments were designed to gain insight into the gene expression of conventional and unconventional murine T cell subsets in the steady state and upon activation TCRαβ and TCRγδ intraepithelial lymphocytes (IEL) isolated from murine gut, naïve and virus-induced memory splenocytes, activated dendritic epidermal T cells (DETC)

2015-03-31 | E-GEOD-63090 | biostudies-arrayexpress

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis [ribo-Seq BRx142]

Project description:Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis [ribo-Seq BRx142]

| PRJNA601135 | ENA

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis [rna-uArray MCF10A]

Project description:Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis [rna-uArray MCF10A]

| PRJNA601133 | ENA

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis [rna-Seq BRx142]

Project description:Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis [rna-Seq BRx142]

| PRJNA601134 | ENA

Gene expression of conventional and unconventional T cell subsets

Project description:The experiments were designed to gain insight into the gene expression of conventional and unconventional murine T cell subsets in the steady state and upon activation

2015-03-31 | GSE63090 | GEO

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis [rna-Seq CTCs 2]

Project description:Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis [rna-Seq CTCs 2]

| PRJNA603789 | ENA