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Tumor DNA methylation profiling of pediatric patients with adrenocortical tumors

ABSTRACT: Tumor DNA methylation profiling of pediatric patients with adrenocortical tumors

PROVIDER: PRJNA742568 | ENA |

REPOSITORIES: ENA

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Tumor DNA methylation profiling of pediatric patients with adrenocortical tumors

Project description:Abnormal DNA methylation contributes to tumor progression and is emerging as a prognostic marker in several types of cancers. To investigate whether DNA methylation is associated with Pediatric Adrenocortical Tumor (pACT) presentation and patient prognosis, we analyzed the methylation profile of 57 tumors (Illumina Infinium HumanMethylation850 BeadChip) and patients’ clinicopathological features and outcome.

2023-01-26 | GSE179175 | GEO

DNA Methylation Profiling Reveals Prognostically Significant Groups in Pediatric Adrenocortical Tumors: A Report From the International Pediatric Adrenocortical Tumor Registry

Project description:Pediatric adrenocortical carcinomas (ACCs) are aggressive; the overall survival of pediatric patients with ACCs is 40%-50%. Appropriate staging and histologic classification are crucial as children with incompletely resected tumors or metastatic disease have a dismal prognosis. The clinical course of pediatric adrenocortical tumors (ACTs) is difficult to predict using the current classification schemas, which rely heavily on subjective microscopic and gross macroscopic variables. Recent advances in adult ACT studies have revealed distinct DNA-methylation patterns with prognostic significance that have not been systematically interrogated in the pediatric population.

2020-05-16 | GSE131350 | GEO

DNA Methylation Profiling Reveals Prognostically Significant Groups in Pediatric Adrenocortical Tumors: A Report From the International Pediatric Adrenocortical Tumor Registry

Project description:DNA Methylation Profiling Reveals Prognostically Significant Groups in Pediatric Adrenocortical Tumors: A Report From the International Pediatric Adrenocortical Tumor Registry

| PRJNA543319 | ENA

microRNA expression profile of pediatric adrenocortical tumors

Project description:microRNA expression profile of pediatric adrenocortical tumors

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Gene exrpression profiling of childhood adrenocortical tumors

Project description:Pediatric adrenocortical tumors (ACT) are rare and often fatal malignancies; little is known regarding their etiology and biology. To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermined) and seven normal adrenal glands. Distinct patterns of gene expression, validated by quantitative real-time PCR and Western blot analysis, were identified that distinguish normal adrenal cortex from tumor. Differences in gene expression were also identified between adrenocortical adenomas and carcinomas. In addition, pediatric adrenocortical carcinomas were found to share similar patterns of gene expression when compared with those published for adult ACT. This study represents the first microarray analysis of childhood ACT. Our findings lay the groundwork for establishing gene expression profiles that may aid in the diagnosis and prognosis of pediatric ACT, and in the identification of signaling pathways that contribute to this disease. We used microarrays to explore the expression profiles differentially expressed in childhood adrenocortical tumors and in normal adrenal gland tissues. Pediatric adrenocortical adenoma and carcinoma patients were enrolled on the International Pediatric Adrenocortical Tumor Registry (IPACTR) and Bank protocol. Tumor specimens were harvested during surgery and snap frozen in liquid nitrogen to preserve tissue integrity. Data have been compiled for eight males and 15 females between 0 and 16 years of age. Table 1 (West et al, Cancer Research 67:601-608, 2007) summarizes the primary clinical information for each subject (excluding sample Unk1 with ACT of undetermined histology), including stage of the disease, tumor class, sex, age, relapse-free survival, and overall survival.

2015-11-25 | E-GEOD-75415 | biostudies-arrayexpress

Gene expression profiling of pediatric adrenocortical tumors collected by the International Pediatric Adrenocortical Tumor Registry (IPACTR).

Project description:We have previously observed that expression of HLA genes associate with histology of adrenocortical tumors (PMID 17234769). Here, we supplement that data with gene expression data on N additional tumors. This submission includes the data from the original study and N additional tumors.

2016-12-14 | GSE76021 | GEO

Gene exrpression profiling of childhood adrenocortical tumors

2015-11-25 | GSE75415 | GEO

Tumor DNA methylation in pediatric germ cell tumors

Project description:Tumor DNA methylation in pediatric germ cell tumors

| PRJNA762030 | ENA

Gene expression profiling of pediatric adrenocortical tumors of patients treated on the Children's Oncology Group XXX protocol.

Project description:We have previously observed that expression of HLA genes associate with histology of adrenocortical tumors (PMID 17234769). Here, we used gene expression microarrays to associate the diagnostic tumor expression of these genes with outcome among 34 patients treated on the COG ARAR0332 protocol.

2016-12-14 | GSE76019 | GEO

Tumor DNA methylation in pediatric germ cell tumors

Project description:Epigenomewide methylation profiling of tumor DNA from pediatric germ cell tumors by sex, tumor histology, tumor location and age at diagnosis. DNA methylation was measured using the Illumina Infinium HumanMethylation450 array

2021-09-11 | GSE183798 | GEO

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