Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury [human]

ABSTRACT: Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury [human]

PROVIDER: PRJNA743868 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury

Project description:Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury

| PRJNA743863 | ENA

Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury [rat]

Project description:Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury [rat]

| PRJNA743869 | ENA

Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury [rat]

Project description:Inhalation of toxic chemicals, including recent e-cigarettes, often cause life-threatening lung injury. Although exposure to polyhexamethylene guanidine (PHMG)-containing humidifier disinfectant (HD) has been identified as a cause of fatal lung injury, the mechanism underlying HD-associated lung injury (HDLI) is unknown. The present study evaluated global changes in gene expression in lung tissues from patients with PHMG-induced HDLI, and compared gene expression changes in PHMG-induced rat lung tissues. Significantly different expressions in lung tissues between patients with HDLI and unaffected controls were observed. Furthermore, several fibrosis-associated overlapping genes (such as MMP2 and COL1A2) shared between humans with HDLI and rats exposed to PHMG were identified. Interactome network analysis predicted different pathways between children and adults with HDLI: the TGFβ/SMAD signaling pathway was central in adults, whereas other pathways, including integrin signaling, were associated with HDLI in children. Further interactome network analysis revealed that Rap1 and CCKR signaling pathways were significantly enriched in HDLI compared with idiopathic pulmonary fibrosis as well as their recapitulation in the lung tissues of rats exposed to PHMG. Our results suggest that MMP2-mediated different mechanisms between children and adults may be associated with PHMG-induced HDLI development, and Rap1 and CCKR pathways appear to be crucial.

2021-07-06 | GSE179446 | GEO

Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury [human]

2021-07-06 | GSE179445 | GEO

Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury.

Project description: Not available

| S-EPMC8567041 | biostudies-literature

Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-07-06 | GSE179447 | GEO

Unravelling the genetic determinants of sinusoidal obstruction syndrome: an integrative multi-omics approach

Project description:Unravelling the genetic determinants of sinusoidal obstruction syndrome: an integrative multi-omics approach

| PRJNA739371 | ENA

Integrative Omics Analysis for Colorectal Cancer and Metastasis

Project description:The pathogenesis of Colorectal cancer (CRC) metastasis remains unclear.We collect clinical data from our center and use Integrative omics to analyze and predict candidate biomarkers of colorectal cancer and distant metastasis.

| 2743637 | ecrin-mdr-crc

Integrative multi-omics analysis in sepsis-associated liver dysfunction

Project description:we conducted integrative multiple levels of omics data including transcriptome, phosphoproteome, proteome and metabolome in different time-course of sepsis-associated liver dysfunction (SALD). This is the first trial to suggest the statistical pathway of integrative multi-omics data in sepsis. Given the increasing number of studies collecting multi-omics data but limited overview of the methodological framework for integrative analyses (Liu, Ding et al. 2013, Petersen, Zeilinger et al. 2014, Shah, Bonder et al. 2015), integrative approach in sepsis with liver dysfunction in this study will provide novel insights into the development of sepsis and ultimately offer new tools for overcoming the present diagnostic limitation. Therefore, a combined multi-omics dataset will give better accessibility of adoption in disease, and insight to identify the promising candidates for therapeutic strategies.

2023-06-21 | PXD025800 | Pride

An integrative omics approach reveals posttranscriptional mechanisms underlying circadian temperature compensation

Project description:An integrative omics approach reveals posttranscriptional mechanisms underlying circadian temperature compensation

| PRJNA771183 | ENA