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Transcriptome analysis of NCC-IT-A3 cells by Barasertib treatment

ABSTRACT: Transcriptome analysis of NCC-IT-A3 cells by Barasertib treatment

PROVIDER: PRJNA744074 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15048676_1.fastq.gz	Fastqsanger.gz
	SRR15048676_2.fastq.gz	Fastqsanger.gz
	SRR15048677_1.fastq.gz	Fastqsanger.gz
	SRR15048677_2.fastq.gz	Fastqsanger.gz
	SRR15048678_1.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of NCC-IT-A3 cells by Barasertib treatment

Project description:During mitosis, the chromosomal passenger complex (CPC) that is formed by Aurora-B, INCENP, Survivin, and Borealin ensures the faithful segregation of the chromosomes into daughter cells. We previously have shown that CPC activity was terminated by the anaphase promoting complex/cyclosome (APC/C) and its cofactor Cdh1 via ubiquitylation of Borealin and Aurora-B during the G1 phase of somatic cells. On the other hand, protein levels of Borealin and Aurora-B were stable during cell cycle progression due to high levels of Emi1, which keep APC/CCdh1 inactive in embryonal carcinoma (EC) cells. During retinoic acid-induced differentiation of EC cells, these proteins were downregulated by APC/CCdh1-mediated ubiquitylation. Interestingly, CPC proteins form a complex with Aurora-B kinase activity even in interphase of EC cells. Significantly, inhibition of CPC activity by either knockdown of Borealin or Aurora-B and Aurora-B kinase inhibitor treatment induced spontaneous differentiation of EC cells. In conclusion, sustained CPC activity plays a critical role in maintenance of the undifferentiated state of pluripotent stem cells. We therefore propose an interphase role of the CPC in regulating embryonic pluripotency.

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