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Multiple modes of regulation control dynamic transcription patterns during the mitosis-G1 transition

ABSTRACT: Multiple modes of regulation control dynamic transcription patterns during the mitosis-G1 transition

PROVIDER: PRJNA744224 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15052413.fastq.gz	Fastqsanger.gz
	SRR15052414.fastq.gz	Fastqsanger.gz
	SRR15052415.fastq.gz	Fastqsanger.gz
	SRR15052416.fastq.gz	Fastqsanger.gz
	SRR15052417.fastq.gz	Fastqsanger.gz

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Multiple modes of regulation control dynamic transcription patterns during the mitosis-G1 transition

Project description:Following cell division, genomes must reactivate gene expression patterns that reflect the identity of the cell. Here, we use PRO-seq to examine the mechanisms that reestablish transcription patterns after mitosis. We uncover regulation of the transcription cycle at multiple steps including initiation, promoter-proximal pause positioning and escape, poly-A site cleavage and termination during the mitotic-G1 transition. During mitosis, RNA polymerase activity is retained at initiation sites, albeit shifted in position relative to non-mitotic cells. This activity is strongly linked to maintenance of local chromatin architecture during mitosis and is more predictive of rapid gene reactivation than histone modifications previously associated with bookmarking. These molecular bookmarks, combined with sequence-specific transcription factors, direct expression of select cell growth and cell specific genes during mitosis followed by reactivation of functional gene groups with distinct kinetics after mitosis. This study details how dynamic regulation of transcription at multiple steps contributes to gene expression during the cell cycle.

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