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Single cell RNA sequencing reveals cellular heterogeneity of DLE and SLE

ABSTRACT: single cell RNA sequencing reveals cellular heterogeneity of DLE and SLE

PROVIDER: PRJNA744430 | ENA |

REPOSITORIES: ENA

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single cell RNA sequencing reveals cellular heterogeneity of DLE and SLE

Project description:Lupus, a server and complex autoimmune disease, is clinically divided into cutaneous lupus erythematosus (CLE) which featured in skin damage, and systemic lupus erythematosus (SLE) which characterized in systemic multi-organ damage. The distinction of these two types of lupus is widely unknown. Here, we collected 23 skin biopsies of healthy control(HC), DLE (discoid lupus erythematosus, a main type of CLE) and SLE, separated epidermis and dermis and performed single cell RNA sequencing through microfluidics based 10x genomics system. Our results demonstrated larger numbers of immune cells infiltrated in skin lesions of DLE than SLE, which may help to distinguish them. Then, non-immune cells such as keratinocytes and fibroblasts were showed functions like immune cells. Moreover, ISGs(interferon stimulated genes), HSP70 coding genes were found to be overexpressed in multi expanded subclusters. Some biological progresses such as autophagy and neutrophil activation were enriched in expanded subclusters.

2022-10-17 | GSE179633 | GEO

Multiplexed scRNA-seq reveals cellular and genetic correlates of SLE

Project description:Multiplexed scRNA-seq reveals cellular and genetic correlates of SLE

| PRJNA807045 | ENA

Multiplexed scRNA-seq reveals cellular and genetic correlates of SLE

Project description:Multiplexed scRNA-seq reveals cellular and genetic correlates of SLE

| PRJNA807046 | ENA

Gene expression from human discoid (DLE) and subacute (sCLE) cutaneous lupus subtypes

Project description:Cutaneous lupus erythematosus (CLE) is a disfiguring disease that can exist as an independent entity or as a manifestation of systemic lupus erythematosus (SLE) where up to 70% of patients experience lesions during their disease course. Subacute CLE (sCLE) is an inflammatory lesion with associated erythema in papulosquamous or annular formations. Typically, sCLE does not scar but depigmentation can occur. Importantly, sCLE is associated with a higher progression to SLE. Discoid lesions (DLE) are often circular and frequently lead to alopecia and scar formation. sCLE lesions have a higher propensity for photoprovocation and a more robust inflammatory infiltrate following ultraviolet (UV) B exposure. The pathogenic mechanisms which govern the differences between DLE and sCLE remain poorly defined, and this is reflected by the refractory nature of cutaneous lesions to usual lupus therapies. In this study, we evaluated the transcriptional profiles of 26 DLE and 23 sCLE biopsies and compared them to control skin and to each other in order to develop a comprehensive understanding of the similarities and differences between these two clinical subtypes.

2017-07-03 | GSE81071 | GEO

Molecular Dissection of Disease Heterogeneity in SLE

Project description:Molecular Dissection of Disease Heterogeneity in SLE

| PRJNA781257 | ENA

A single cell approach to map cellular subsets involved in Systemic Lupus Erythematosus (SLE) heterogeneity

Project description:A single cell approach to map cellular subsets involved in Systemic Lupus Erythematosus (SLE) heterogeneity

| PRJNA560047 | ENA

Transcriptomics reveals novel molecular features of SLE severity

Project description:Complex blood transcriptomes can lead to the clinical heterogeneity of systemic lupus erythematosus (SLE). In the current study, we integrated transcriptomics, public data mining and clinical parameters to reveal whether SLE severity is affected by specific genes or pathways.

2024-06-20 | GSE228066 | GEO

Mapping SLE heterogeneity at the single cell level

Project description:Mapping SLE heterogeneity at the single cell level

| PRJNA640196 | ENA

Mapping SLE heterogeneity at the single cell level

Project description:Mapping SLE heterogeneity at the single cell level

| PRJNA640197 | ENA

LC-MS of PBMC in SLE and healthy control

Project description:Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease that displays a significant gender difference in terms of incidence and severity. However, the underlying mechanisms accounting for sexual dimorphism remain unclear. To reveal the heterogeneity in the pathogenesis of SLE between male and female patients. PBMC were collected from 15 patients with SLE (7 males, 8 females) and 15 age-matched healthy controls (7 males, 8 females) for proteomic analysis. Enrichment analysis of proteomic data revealed that type I interferon signaling and neutrophil activation networks mapped to both male and female SLE, while male SLE has a higher level of neutrophil activation compared with female SLE. Our findings define gender heterogeneity in the pathogenesis of SLE and may facilitate the development of gender-specific treatments.

2022-08-12 | PXD033144 | Pride

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