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Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [ChIP-Seq]

ABSTRACT: Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [ChIP-Seq]

PROVIDER: PRJNA744859 | ENA |

REPOSITORIES: ENA

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Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells

Project description:Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells

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Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [CITEseq]

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Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [inDrop]

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Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [bulk RNA-seq]

Project description:Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [bulk RNA-seq]

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Project description:Leukemia initiating cells (LICs) self-renew indefinitely to fuel leukemic growth and spark disease relapse. Previously thought to be primitive and rare, the LIC state may actually be heterogeneous and dynamic, allowing LICs to evade therapy. Here, we use single cell transcriptomics to dissect the ontogeny of MLL-rearranged B-lymphoblastic leukemia (MLL-r B-ALL). Although we identify primitive, rare LICs, we also find more phenotypically differentiated LICs that possess the capability to replenish the full cellular diversity of MLL-r B-ALL. We find that activation of MYC-driven oxidative phosphorylation drives this process of cell state conversion, defining a new mechanism of LIC plasticity.

2022-03-24 | GSE147860 | GEO

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2022-03-24 | GSE179733 | GEO

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2022-03-24 | GSE147861 | GEO

Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [ChIP-Seq]

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Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [bulk RNA-seq]

2022-03-24 | GSE147859 | GEO