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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [Hi-C]

ABSTRACT: Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [Hi-C]

PROVIDER: PRJNA744928 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15075467_1.fastq.gz	Fastqsanger.gz
	SRR15075467_2.fastq.gz	Fastqsanger.gz
	SRR15075468_1.fastq.gz	Fastqsanger.gz
	SRR15075468_2.fastq.gz	Fastqsanger.gz
	SRR15075469_1.fastq.gz	Fastqsanger.gz

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [CTCF Cut&Run]

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [CTCF Cut&Run]

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [Hi-C]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [RNA-Seq]

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [RNA-Seq]

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [DNase-Seq]

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [DNase-Seq]

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [CTCF Cut&Run]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [RNA-Seq]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [DNase-Seq]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

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DNA-guided transcription factor cooperativity shapes face and limb mesenchyme [ATAC-seq]

Project description:Transcription factors (TFs) can define distinct cellular identities despite nearly identical DNA-binding specificities. One mechanism for achieving regulatory specificity is DNA-guided TF cooperativity. Although in vitro studies suggest it may be common, examples of such cooperativity remain scarce in cellular contexts. Here, we demonstrate how ‘Coordinator’, a long DNA motif comprised of common motifs bound by many basic helix-loop-helix (bHLH) and homeodomain (HD) TFs, uniquely defines regulatory regions of embryonic face and limb mesenchyme. Coordinator guides cooperative and selective binding between the bHLH family mesenchymal regulator TWIST1 and a collective of HD factors associated with regional identities in the face and limb. TWIST1 is required for HD binding and open chromatin at Coordinator sites, while HD factors stabilize TWIST1 occupancy at Coordinator and titrate it away from HD-independent sites. This cooperativity results in shared regulation of genes involved in cell-type and positional identities, and ultimately shapes facial morphology and evolution.

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