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Sturgeon chondroitin sulfates inhibit the proliferation of colorectal cancer cells by inducing cell cycle arrest and apoptosis

ABSTRACT: Sturgeon chondroitin sulfates inhibit the proliferation of colorectal cancer cells by inducing cell cycle arrest and apoptosis

PROVIDER: PRJNA745352 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15096378_1.fastq.gz	Fastqsanger.gz
	SRR15096378_2.fastq.gz	Fastqsanger.gz
	SRR15096379_1.fastq.gz	Fastqsanger.gz
	SRR15096379_2.fastq.gz	Fastqsanger.gz
	SRR15096380_1.fastq.gz	Fastqsanger.gz

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Sturgeon chondroitin sulfates inhibit the proliferation of colorectal cancer cells by inducing cell cycle arrest and apoptosis

Project description:Cell proliferation assay and flow cytometric analysis were used to examine the effects of SCS treatment on viability and apoptosis of colon cancer cell HT-29 cells and normal colonic epithelial cell NCM460 cells. Transcriptomic and proteomic studies were used to identify the main targets of SCS. SCS showed little effect on the gene expression profile of NCM460 cells whereas188 genes and 10 proteins were differentially regulated in HT-29 cells after SCS treatment. Enrichment analysis of those genes / proteins showed that majority of them are involved in DNA replication, cell cycle progression, and apoptosis.

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Sex-biased expression of miRNAs by microarray in critically endangered Amur sturgeon

Project description:In this study, we utilized the microfluidics chip technology on the gonads of Amur sturgeon to identifiy gender-specific miRNAs. The probes of all miRNAs about 663 published in fish and our novel miRNAs from sturgeon were chosed in the microarray experiment. Above 4Âµg to 8Âµg total RNA from one female and one male separativley were performed the miRNA microarray assays.Each probe was repeated five times on the chip to ensure reproducibility of microarray.

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Sex-biased expression of miRNAs by microarray in critically endangered Amur sturgeon

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Tissue expression profiling of miRNAs in Amur sturgeon (Acipenser schrenckii)

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Effects of different fat source diets on the transcriptome of brain, liver and spleen in Yangze sturgeon

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