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The effect of periodontitis - induced trained immunity

ABSTRACT: The effect of periodontitis - induced trained immunity

PROVIDER: PRJNA746302 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15117310.fastq.gz	Fastqsanger.gz
	SRR15117311.fastq.gz	Fastqsanger.gz
	SRR15117312.fastq.gz	Fastqsanger.gz
	SRR15117313.fastq.gz	Fastqsanger.gz
	SRR15117314.fastq.gz	Fastqsanger.gz

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The effect of periodontitis - induced trained immunity on the transcriptomic profile of mouse LSK cells [RNA-seq]

Project description:The effect of periodontitis - induced trained immunity on the transcriptomic profile of mouse LSK cells [RNA-seq]

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The effect of periodontitis - induced trained immunity on the epigenomic profile of mouse bone marrow LSK and GMP cells

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Hydroxychloroquine inhibits trained immunity

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RNA-Seq of BMDM from aged mice and the effect of trained immunity

Project description:We generated BMDMs from aged C57BL/6J mice. BMDMs were treated with C.ablican derived β-glucan, which is known to induce trained immunity. mRNA was isolated form immune trained and control BMDMs using the Rneasy Kit from Qiagen. Library preparation and sequencing performed by Novogene. We found that trained immunity induced transcriptional changes in BMDMs from aged mice

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Project description:The innate immune system plays an essential role in regulating the immune responses to kidney transplantation, but the mechanisms through which innate immune cells influence long-term graft survival are unclear. The current study highlights the vital role of trained immunity in kidney allograft survival. Trained immunity describes the epigenetic and metabolic changes that innate immune cells undergo following an initial stimulus, allowing them have a stronger inflammatory response to subsequent stimuli. We stimulated healthy peripheral blood mononuclear cells with pretransplant and posttransplant serum of kidney transplant patients and immunosuppressive drugs in an in vitro trained immunity assay and measured tumor necrosis factor and interleukin 6 cytokine levels in the supernatant as a readout for trained immunity. We show that the serum of kidney transplant recipients collected 1 week after transplantation can suppress trained immunity. Importantly, we found that kidney transplant recipients whose serum most strongly suppressed trained immunity rarely experienced graft loss. This suppressive effect of posttransplant serum is likely mediated by previously unreported effects of immunosuppressive drugs. Our findings provide mechanistic insights into the role of innate immunity in kidney allograft survival, uncovering trained immunity as a potential therapeutic target for improving graft survival.

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