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Comprehensive Atlas of the Mouse Urinary Bladder

ABSTRACT: Comprehensive Atlas of the Mouse Urinary Bladder

PROVIDER: PRJNA746602 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR15142377.fastq.gz	Fastqsanger.gz
	SRR15142378.fastq.gz	Fastqsanger.gz
	SRR15142379_1.fastq.gz	Fastqsanger.gz
	SRR15142379_2.fastq.gz	Fastqsanger.gz

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Comprehensive Atlas of the Mouse Urinary Bladder

Project description:We report the application of single-cell based sequencing for high throughput profiling of the mouse urinary bladder. By utilizing multiple dissociation techniques and library preparation techniques we generated an atlas comprising 43,119 cells including major cell types absent from previous reports. We found that previous single-cell profiling of the mouse bladder lacked a major cell type in the detrusor smooth muscle and incorrectly annotated other cell types such as mesothelial cells. Using the atlas, we elucidated aspects of bladder biology including urothelial differentiation, the identity of interstitial cells of Cajal, detrusor smooth muscle control and immune distributions. Finally, we combine the single-cell based sequencing with spatial transcriptomics and imaging mass cytometry to add spatial context to transcriptomic profiling.

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