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Marginal zone B cells leverage the Notch2-Myc-mTORC1 signaling axis to achieve division independent plasma cell differentiation.

ABSTRACT: Marginal zone B cells leverage the Notch2-Myc-mTORC1 signaling axis to achieve division independent plasma cell differentiation.

PROVIDER: PRJNA746956 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15150300.fastq.gz	Fastqsanger.gz
	SRR15150301.fastq.gz	Fastqsanger.gz
	SRR15150302.fastq.gz	Fastqsanger.gz
	SRR15150303.fastq.gz	Fastqsanger.gz
	SRR15150304.fastq.gz	Fastqsanger.gz

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Identification of Myc-dependent and -independent Notch2 signatures in marginal zone B cells.

Project description:Marginal zone (MZ) B cells leverage Notch2 signals to attain rapid differentiation responses and positional cues with in the spenic environment. While it is known that a major player in Notch2 signaling in MZ B cells is the proto-oncogene Myc, it is not clear to what extent MZ B cells use Notch2 signals in Myc-independent manner. In this study we conditinally and inducibly deleted Myc in mature B cells and then used in vivo delivery of anti-Notch2 antibodies to separated Myc-dependent and -independent Notch2 signaling in MZ B cells.

2024-10-18 | GSE274989 | GEO

Transcriptomic analyis follicular and marginal zone B ells after in vivo Notch2 blockade.

Project description:Marginal zone B cells which make rapid mitosis-independent plasma cell responses are dependent on Notch2 signaling for their generation and maintenance. In order to determine the effect of ongoing Notch signaling on the maintenance of the MZ transcriptome, we performed RNA-seq on MZ and follicular B cells after 12, 24 and 48 hours of in vivo Notch2 antibody blockade

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Marginal zone B cells receive robust Notch2 signals within the B cell follicle in the absense of S1pr1 signaling.

Project description:Marginal zone (MZ) B cells have innate-like response characteristics due to a unique ability receive and integrate Notch2 signals in the spleen. There is evidence showing MZ B cells receive these signals both in the marginal sinus and the B cell follicle. The relative strength and conservation of these Notch signals is not yet clear. Therefore, we generated mice in which S1pr1 is deleted in mature B cells. These mice have MZ B cells by phenotype but these cells are retained in the follicle and unable to transit to the marginal zone. In this experiment we examined the impact of Notch2 signaling in these cells and cre expressing control animals using in vivo anti-Notch2 antibody blockade followed by RNA-sequencing.

2024-10-18 | GSE274990 | GEO

Marginal zone B cells leverage the Notch2-Myc-mTORC1 signaling axis to achieve division independent plasma cell differentiation.

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-07-22 | GSE180174 | GEO

Notch2 Signaling Induces Trans-differentiation of Follicular to Marginal Zone B Cells

Project description:Notch2 Signaling Induces Trans-differentiation of Follicular to Marginal Zone B Cells

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Transcriptomic analyis follicular and marginal zone B ells after in vivo Notch2 blockade.

Project description:Transcriptomic analyis follicular and marginal zone B ells after in vivo Notch2 blockade.

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Identification of Myc-dependent and -independent Notch2 signatures in marginal zone B cells.

Project description:Identification of Myc-dependent and -independent Notch2 signatures in marginal zone B cells.

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Human splenic marginal zone precursors (MZP) differentiation into marginal zone B cells (MZB)through a Notch2 signalling pathway

Project description:RNA microarray profiling analysis was performed on different ex-vivo human splenic B cell subsets (M-^SNaM-oveM-^T, marginal zone precursors or M-^SMZPM-^T, marginal zone B cells orM-^T MZBM-^T, M-^SMTG+CD45+M-^T cells) and on M-^Sp27M-^T cells, corresponding to the fraction of MZP cells that differentiated into CD27-expressing cells after culture on OP9-hDLL1 cells cultured with OP9-hDLL1 cells that differentiated into CD27-expressing cells

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NOTCH2 mutants

Project description:NOTCH2 mutants

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Identification of Notch ligand useage by splenic B cells using Dll1 and Dll4 Notch ligand blockade.

Project description:Marginal zone (MZ) B cells leverage Notch2 signals to attain rapid differentiation responses and positional cues with in the spenic environment.To determine the likely molecular source of Notch2 signals we sought to block the Notch ligands delta-like ligand 1 (Dll1) and delta-like ligand 4 (Dll4) in wildtype mice using in-vivo treatment with monoclonal blocking antibodies. Splenic populations of MZ B cells and follicular B cells were sort purified after 12, 24 and 48 hours of blockade and analyzed by RNA-seq.

2024-10-18 | GSE274991 | GEO

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