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Resitant populations to photodynamic therapy (PDT) of squamous cell carcinoma cells (SCC-13)

ABSTRACT: Resitant populations to photodynamic therapy (PDT) of squamous cell carcinoma cells (SCC-13)

PROVIDER: PRJNA747827 | ENA |

REPOSITORIES: ENA

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Human SCC-13 Cells: Control vs. Resitant populations to photodynamic therapy (PDT)

Project description:aCGH of control cells not subjected to PDT (Parental) and cells subjected to 5 or 10 sequential PDT treatments (5M-BM-:G and 10M-BM-:G, respectively). Three-condition experiment, cultures of SCC-13 cells not subjected to PDT (Parental) vs 5M-BM-:G and 10M-BM-:G generations of resistant cells.

2013-09-06 | E-GEOD-50602 | biostudies-arrayexpress

Resitant populations to photodynamic therapy (PDT) of squamous cell carcinoma cells (SCC-13)

Project description:aCGH of control cells not subjected to PDT (Parental), cells subjected to 10 sequential PDT treatments (10G) and 10G cells inoculated in immunosuppressed mice; the induced tumors were subcultured by explants to obtain a cell resistant population called 10GT

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miRNA expression profiling in squamous cell carcinoma (SCC)

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2013-01-18 | E-GEOD-32868 | biostudies-arrayexpress

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ArrayCGH mapping of chromosome 3 aberrations in lung Squamous Cell Carcinoma (SCC)

Project description:To prospectively identify new oncogenes implicated in lung Squamous Cell Carcinoma pathogenesis, we investigated chromosome 3 aberrations in advanced tumours using arrayCGH. These aberrations are indeed among the most frequent aberrations in lung SCC and correlate with SCC patient's poor prognosis. We precisely map regions of recurrent losses at 3p and gains at 3q25-qter in a series of lung SCC. We moreover uncover 3q26.3-q27 high level amplifications in 20% of tumours. Keywords: ArrayCGH, Lung Squamous Cell Carcinoma, 3q26.3, SOX2

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The Role of JNK1/2 in Mouse Lung Squamous Cell Carcinoma (SCC) Development

Project description:Lung cancer is the leading cause of cancer death in USA. Squamous Cell Carcinoma (SCC) is one of the subtypes of lung cancer. It is still largely unknown which genes or pathways regulate lung SCC development. Recently, we found JNK1/2 pathway was inhibited in mouse lung SCC induced by double ablation of Pten and Lkb1 in mouse lung epithelial cells. Now we aim to identify a genome-wide molecular signature of JNK1/2 signaling in mouse squamous cell carcinoma cells and determine pathways that transduce JNK1/2 signaling.

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Human SCC-13 Cells: Control vs. Resitant populations to photodynamic therapy (PDT)

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ArrayCGH mapping of the recurrent 3q26.3-q27 amplifications in lung Squamous Cell Carcinoma (SCC)

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