Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rickettsiales bacterium

ABSTRACT: Rickettsiales bacterium overview

PROVIDER: PRJNA748484 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR6053176_1.fastq.gz	Fastqsanger.gz
	SRR6053176_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 3 of 3

Similar Datasets

Rickettsiales bacterium Ac37b

Project description:Rickettsiales bacterium Ac37b Genome sequencing

| PRJNA256465 | ENA

Rickettsiales bacterium

Project description:Marine Rickettsiales genomes

| PRJNA746308 | ENA

Rickettsiales bacterium strain:JGI CrystG Aug08-2-H10

Project description:Rickettsiales bacterium strain:JGI CrystG Aug08-2-H10 Genome sequencing

| PRJNA403030 | ENA

Rickettsiales genera incertae sedis

Project description:Rickettsiales genera incertae sedis Genome sequencing

| PRJNA254818 | ENA

Rickettsiales [taxid 766]

Project description:Genome sequencing and assembly of Rickettsiales bacteria associated with ciliate protists

| PRJNA831616 | ENA

bacterium

Project description:bacterium overview

| PRJNA330746 | ENA

Revisiting Ehrlichia ruminantium Replication Cycle Using Proteomics : The Host and the Bacterium Perspectives

Project description:The Rickettsiales Ehrlichia ruminantium (ER), the causal agent of the fatal tick-borne disease Heartwater, induces severe damage to the vascular endothelium in ruminants. Nevertheless, E. ruminantium-induced pathobiology remains largely unknown. Our work paves the way for understanding this phenomenon by using quantitative proteomic analyses (2D-DIGE-MS/MS, 1DE-nanoLC-MS/MS and biotin-nanoUPLC-MS/MS) of host bovine aorta endothelial cells (BAE) during the in vitro bacterium intracellular replication cycle. We detect 265 bacterial proteins (including virulence factors), at all time-points of the E. ruminantium replication cycle, highlighting a dynamic bacterium–host interaction. We show that E. ruminantium infection modulates the expression of 433 host proteins: 98 being over-expressed, 161 under-expressed, 140 detected only in infected BAE cells and 34 exclusively detected in non-infected cells. Cystoscape integrated data analysis shows that these proteins lead to major changes in host cell immune responses, host cell metabolism and vesicle trafficking, with a clear involvement of inflammation-related proteins in this process. Our findings led to the first model of E. ruminantium infection in host cells in vitro, and we highlight potential biomarkers of E. ruminantium infection in endothelial cells (such as ROCK1, TMEM16K, Albumin and PTPN1), which may be important to further combat Heartwater, namely by developing non-antibiotic-based strategies.

2021-07-14 | PXD026092 | Pride

Nocardioidaceae bacterium

Project description:Nocardioidaceae bacterium overview

| PRJNA733262 | ENA

Gemmatimonadales bacterium

Project description:Gemmatimonadales bacterium overview

| PRJNA495093 | ENA

Alphaproteobacteria bacterium

Project description:Alphaproteobacteria bacterium overview

| PRJNA492613 | ENA