Ontology highlight
ABSTRACT:
PROVIDER: PRJNA748896 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR15214133.fastq.gz | Fastqsanger.gz | |||
| SRR15214133_1.fastq.gz | Fastqsanger.gz | |||
| SRR15214133_2.fastq.gz | Fastqsanger.gz | |||
| SRR15214134.fastq.gz | Fastqsanger.gz | |||
| SRR15214134_1.fastq.gz | Fastqsanger.gz |
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Project description:Newcastle disease (ND) affects a few hundred avian species including chicken, and the clinical outcome of Newcastle disease virus (NDV) infection ranges from mild to severe fatal disease depending on the NDV pathotype and the host species involved. Japanese quails serve as natural reservoirs of NDV and play important role in NDV epidemiology. While infection of chicken with velogenic NDV results in severe often fatal illness, the same infection in Japanese quails is results in in apparent infection. The molecular basis of this contrasting clinical outcomes of NDV infection is not yet known. We compared global gene expression in spleens of chicken and Japanese quails infected with a lentogenic or velogenic NDVs. We found contrasting regulation of key genes associated with NF-κB pathway and T-cell activation between chicken and Japanese quails. Our data suggests association of NDV resistance in Japanese quails to activation of NF-κB pathway and T cell proliferation.
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Project description:MicroRNAs, a class of small non-coding RNAs, play an important role as gene regulators in an array of biological pathways and physiological functions across animal species including Japanese quails. In this study, we profiled and cataloged microRNAs derived from ileum mucosa of Japanese quails with different Phosphorus (P) utility. The aims of this study were to identify differentially expressed miRNAs between high- and low-P utilization groups and to determine candidate microRNAs, target genes and pathways related to P utility in Quail.
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