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TWAS-based translational genomics approach identifies IL10RB as the top candidate gene for COVID-19 host susceptibility and severity

ABSTRACT: TWAS-based translational genomics approach identifies IL10RB as the top candidate gene for COVID-19 host susceptibility and severity

PROVIDER: PRJNA748962 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15215300_1.fastq.gz	Fastqsanger.gz
	SRR15215300_2.fastq.gz	Fastqsanger.gz
	SRR15215301_1.fastq.gz	Fastqsanger.gz
	SRR15215301_2.fastq.gz	Fastqsanger.gz
	SRR15215302_1.fastq.gz	Fastqsanger.gz

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TWAS-based translational genomics approach identifies IL10RB as the top candidate gene for COVID-19 host susceptibility and severity

Project description:Recent efforts have identified genetic loci that are associated with coronavirus disease 2019 (COVID-19) infection rates and disease outcome severity. Translating these genetic findings into druggable genes that regulate COVID-19 host susceptibility is a critical next step. Using a translational genomics approach that integrates COVID-19 genetic susceptibility variants, multi-tissue genetically regulated gene expression (GReX) and perturbagen signatures, we identify IL10RB as the top key regulator of COVID-19 host susceptibility. In a series of validation steps we show that predicted GReX up-regulation of IL10RB and higher IL10RB expression in COVID-19 patient blood is associated with worse COVID-19 outcomes, and that in vitro IL10RB overexpression is associated with increased viral load and activation of disease-relevant molecular pathways.

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