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Effect of MiaPaCa-2 cancer cells on gene expression in HEI-286 Schwann cells and c-Jun KO HEI-286 Schwan cells

ABSTRACT: Effect of MiaPaCa-2 cancer cells on gene expression in HEI-286 Schwann cells and c-Jun KO HEI-286 Schwan cells

PROVIDER: PRJNA749266 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15225676_1.fastq.gz	Fastqsanger.gz
	SRR15225676_2.fastq.gz	Fastqsanger.gz
	SRR15225677_1.fastq.gz	Fastqsanger.gz
	SRR15225677_2.fastq.gz	Fastqsanger.gz
	SRR15225678_1.fastq.gz	Fastqsanger.gz

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Effect of MiaPaCa-2 cancer cells on gene expression in HEI-286 Schwann cells and c-Jun KO HEI-286 Schwan cells

Project description:We report the transcriptome analysis of control and c-Jun knock-out HEI-286 human Schwann cells in presence or absence of cancer cells

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Gene expression level of HEI-286 Schwann cells and MiaPaCa-2 pancreatic cancer cells

Project description:We report the transcriptome analysis of HEI-286 human Schwann cells and MiaPaCa-2 pancreatic cancer cells Nerves stimulate cancer progression for different cancer types, promoting both tumor growth and perineural invasion, a prominent process in pancreatic ductal adenocarcinoma. Yet little is known about how cells in the nerves contribute to cancer progression. Here we demonstrate that Schwann cells, the most abundant cell type in nerves, collectively function as tumor activated Schwann cell tracks (TASTs). Schwann cells in a 3D matrix organize into stellate tracks which serve as a conduit for cancer cell migration. TASTs actively promote pancreatic cancer dissemination during perineural invasion and neoneurogenesis. This key function of TASTs is induced by cancer cells triggering c-Jun activation of Schwann cells, analogous to the reprogramming that promotes nerve repair. In TASTs, dynamic Schwann cell processes wrap around and apply forces directly on cancer cells to enhance cancer motility. We define a model of cancer progression that relies upon collective Schwann cell behavior driven by c-Jun transcriptional reprogramming.

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Gene expression level of HEI-286 Schwann cells and MiaPaCa-2 pancreatic cancer cells

Project description:Gene expression level of HEI-286 Schwann cells and MiaPaCa-2 pancreatic cancer cells

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Expression data of MIAPaCa-2 cells transfected with NDRG1

Project description:NDRG1 functions as a metastasis suppressor in pancreatic and other cancers. To determine the molecular function of NDRG1 in MIAPaCa-2 pancreatic cancer cells, we performed a whole genome gene array analysis on these cells stably transfected with NDRG1 when compared to empty vector-transfected controls. The differentially expressed genes indetified in this microarray may represent potential molecular targets of NDRG1 in pancreatic cancer. Two separate RNA extracts of MIAPaCa-2 vector control and NDRG1 transfected cells were collected and hybridised to Affymetrix Human Genome U133 Plus 2.0 chips.

2011-07-22 | E-GEOD-25086 | biostudies-arrayexpress

Gene expression changes in HEI-193 (NF2-deficient Schwannoma) cells by Nf18001 or TEW7197 treatment.

Project description:Loss of NF2 (merlin) has been suggested as a genetic cause of neurofibromatosis type 2 and malignant peripheral nerve sheath tumor (MPNST). Previously, we demonstrated that NF2 sustained TGF- receptor 2 (TR2) expression and reduction or loss of NF2 activated non-canonical TGF- signaling, which reduced RKIP expression via TR1 kinase activity. Here, we show that a selective RKIP inducer (novel chemical, Nf18001) inhibits tumor growth and promotes schwannoma cell differentiation into mature Schwann cells under NF2-deficient conditions. In addition, Nf18001 is not cytotoxic to cells expressing NF2 and is not disturb canonical TGF- signaling. Moreover, the novel chemical induces expression of SOX10, a marker of differentiated Schwann cells, and promotes nuclear export and degradation of SOX2, a stem cell factor. Treatment with Nf18001 inhibited tumor growth in an allograft model with mouse schwannoma cells. These results strongly suggest that selective RKIP inducers could be useful for the treatment of neurofibromatosis type 2 as well as NF2-deficient MPNST. To know the global effect of Nf18001, we performed the microarray with HEI-193.

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Gene expression of leaders and laggers MiaPaCa-2 pancreatic cancer cells during perineural invasion

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