Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Myocardial cellular gene expression during pressure overload: evidence for transient partial endothelial to mesenchymal transition [Ribo-seq]

ABSTRACT: Myocardial cellular gene expression during pressure overload: evidence for transient partial endothelial to mesenchymal transition [Ribo-seq]

PROVIDER: PRJNA749295 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15228866.fastq.gz	Fastqsanger.gz
	SRR15228867.fastq.gz	Fastqsanger.gz
	SRR15228868.fastq.gz	Fastqsanger.gz
	SRR15228869.fastq.gz	Fastqsanger.gz
	SRR15228870.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Myocardial cellular gene expression during pressure overload: evidence for transient partial endothelial to mesenchymal transition [Ribo-seq]

Project description:Pathological processes underlying pressure overload triggered heart failure were mainly analyzed from a cardiomyocyte centric view. To identify new cellular mechanisms, we isolated cardiomyocytes, endothelial cells and fibroblasts as most abundant cardiac cell types from mice in the subacute and chronic stages of pressure overload (by transverse aortic constriction, TAC) and performed RNA-sequencing. We detected highly cell-type specific transcriptional responses with characteristic time courses and active intercellular communication, especially early after TAC. We focused on endothelial cells, and single-cell sequencing in this population showed enhanced expression of collagens and inflammatory mediators at this stage. Importantly, these endothelial transcriptional changes were transduced to the translational level as shown by Ribo-Tag sequencing and verification of collagen protein production by cardiac endothelial cells. In conclusion, we provide a resource of cardiac cellular gene expression in pressure overload and reveal the induction of collagens by endothelial cells as potential therapeutic target.

2022-02-08 | GSE180733 | GEO

Myocardial cellular gene expression during pressure overload: evidence for transient partial endothelial to mesenchymal transition [scDROP-seq]

2022-02-08 | GSE180736 | GEO

Myocardial cellular gene expression during pressure overload: evidence for transient partial endothelial to mesenchymal transition [Bulk RNA-seq]

2022-02-08 | GSE180720 | GEO

Myocardial cellular gene expression during pressure overload: evidence for transient partial endothelial to mesenchymal transition [scDROP-seq]

Project description:Myocardial cellular gene expression during pressure overload: evidence for transient partial endothelial to mesenchymal transition [scDROP-seq]

| PRJNA749577 | ENA

Myocardial cellular gene expression during pressure overload: evidence for transient partial endothelial to mesenchymal transition [Bulk RNA-seq]

Project description:Myocardial cellular gene expression during pressure overload: evidence for transient partial endothelial to mesenchymal transition [Bulk RNA-seq]

| PRJNA749281 | ENA

Myocardial gene expression in response to pressure overload

Project description:Myocardial deletion of klf4 sensitizes mouse to pressure overload. In order to gain a better understanding of molecular mechanisms of such alterations, we profiled gene expression before and after 3-day of pressure overload (induced by transverse aortic constriction -TAC) in the hearts from MHC-cre (Cre) control and MHC-cre-klf4-deficient (KO) mice. 10wk old male mice was subjected to transverse aortic constriction (TAC) to induce pressure overload or sham operation as control group. After 3 days, heart was removed and total RNA was extracted from apex and subjected for array analysis. Four animals in each group.

2015-07-01 | E-GEOD-61177 | biostudies-arrayexpress

Pressure-Overload Induced Cardiac Hypertrophy

Project description:Aortic banding is an excellent model system to evaluate the process of development of left ventricular hypertrophy in response to hemodynamic stress. The Affymetrix GeneChip MgU74Av1 was used to analyze expression profiles of mice at different time points after surgical intervention for pressure-overload induced hypertrophy. More information about this model may be obtained at http://cardiogenomics.med.harvard.edu/groups/proj1/pages/band_home.html Keywords = Pressure overload, cardiac hypertrophy Keywords: time-course

2002-07-30 | GSE76 | GEO

Pressure overload cardiac hypertrophy

Project description:Expression profiling of hearts from FVB males subjected to cardiac pressure overload by transverse aortic constriction (TAC). TAC performed on 8-10 weeks month old males and females. Hearts examined 30 weeks after surgery. Keywords: ordered

2005-06-29 | GSE2459 | GEO

Myocardial gene expression in response to pressure overload

2015-07-01 | GSE61177 | GEO

IL-18 and Pressure Overload-induced Cardiac Hypertrophy

Project description:Pressure overload-induced cardiac hypertrophy was examined in IL-18 knockout and littermate control mice. Keywords: genetic modification / disease model

2006-07-04 | GSE5129 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data