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Tex10 in primordial gem cell-like cell (PGCLC) specification and spermatogenesis

ABSTRACT: Tex10 in primordial gem cell-like cell (PGCLC) specification and spermatogenesis

PROVIDER: PRJNA749589 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15242600_1.fastq.gz	Fastqsanger.gz
	SRR15242600_2.fastq.gz	Fastqsanger.gz
	SRR15242601_1.fastq.gz	Fastqsanger.gz
	SRR15242601_2.fastq.gz	Fastqsanger.gz
	SRR15242602_1.fastq.gz	Fastqsanger.gz

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Tex10 in primordial gem cell-like cell (PGCLC) specification and spermatogenesis

Project description:Tex10 depletion compromises the PGCLC specification and spermatogenesis

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Transcriptional changes of Tex10 in purified primordial gem cell-like cells (PGCLCs) at day2 and day6

Project description:Testis-specific transcript 10 (Tex10) is highly expressed in the testis, embryonic stem cells (ESCs), and primordial germ cells (PGCs). We previously generated a Tex10 knockout mouse model demonstrating its critical roles in ESC pluripotency and preimplantation development. Here, using conditional knockout mice and dTAG-degron ESCs, we show Tex10 is required for spermatogenesis and ESC-to-PGCLC differentiation. Specifically, Tex10-null spermatocytes arrest at metaphase I, compromising round spermatid formation. Tex10 depletion and overexpression compromise and enhance ESC-to-PGCLC differentiation, respectively. Mechanistically, bulk and single-cell RNA sequencing reveals that Tex10 depletion downregulates genes involved in pluripotency, PGC development, and spermatogenesis while upregulating genes promoting somatic programs. Chromatin occupancy study reveals that Tex10 binds to H3K4me3-marked promoters of Psmd3 and Psmd7, negative regulators of Wnt signaling, and activates their expression, thereby restraining Wnt signaling. Our study identifies Tex10 as a previously unappreciated factor in spermatogenesis and PGC development, offering potential therapeutic insights for treating male infertility.

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Transcriptional changes of spermatogenic cells by Tex10 deficiency

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Project description:We report the Tex10 binding and genome-wide map of H3K4me3 modification in Day 2 PGCLCs by chromatin immunoprecipitation sequencing.

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Tex10 in PGCLC specification and spermatogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-06-14 | GSE180801 | GEO

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Project description:GEM-CESAR

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