Project description:Primary objectives: The primary objective is to investigate circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Primary endpoints: circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Project description:Kaempferitrin is extracted in significantly high quantities from the leaves of Cinnamomum osmophloeum, which belongs to the genus Cinnamomum, the same genus many antidiabetic herbal remedy in Chinese medicine. Oral administration of kaempferitrin reduces blood sugar in alloxan-induced diabetic rats. In this project, we studied the differential expression profile with proteomic approach using the liver cancer cell line hepG2, as liver cells were responsible for the regulation of lipid generation systemically.
2021-02-01 | PXD022181 | Pride
Project description:Whole genome sequencing of Cinnamomum camphora