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Fourteen commensals restore immunocompetence in adult germfree mice via maturation of the intestinal vascular system

ABSTRACT: Fourteen commensals restore immunocompetence in adult germfree mice via maturation of the intestinal vascular system

PROVIDER: PRJNA750057 | ENA |

REPOSITORIES: ENA

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From carrier to responder - few commensals restore immunocompetence in adult germfree mice via maturation of the intestinal vascular system

Project description:From carrier to responder - few commensals restore immunocompetence in adult germfree mice via maturation of the intestinal vascular system

| PRJNA746783 | ENA

From carrier to responder - few commensals restore immunocompetence in adult germfree mice via maturation of the intestinal vascular system

Project description:The intestinal microbiota fundamentally influences the development of a normal intestinal physiology and education and functioning of the mucosal immune system. Using the C. rodentium carrier model of germfree mice (GF), we found that colonization of adult GF with 14 selected commensals (OMM12+MC2) was sufficient to convert a carriers into responders through maturation of intestinal crypts, increasing intestinal angiogenesis and stimulation of the immune system. While the immature colon of C. rodentium infected GF did not allow sufficient extravasation of neutrophils into the gut lumen, colonization with these commensals triggered activation and proliferation of endothelial cells, enabling granulocytes to transmigrate into the gut lumen. Enhanced angiogenesis and morphological maturation development of the intestine was most likely due to sensing of commensals by Paneth cells and subsequent secretion of antimicrobial peptides and angiogenetic factors. This demonstrates the therapeutic value of few commensal bacteria to complete morphological and immunological maturation in of the adult intestinal mucosa enabling rendering this organ immunocompetent against infections and responsive to therapies.

2021-09-09 | GSE180156 | GEO

Fourteen commensals restore immunocompetence in adult germfree mice via maturation of the intestinal vascular system

Project description:The intestinal microbiota influences the development of a normal intestinal physiology, education and functioning of the mucosal immune system. The goal of this study is to analyze how the transcriptional profile of the colonic endothelial cells is influence by colonization of gnotobiotic mice with specific bacterial strains . The goal of this study is to analyze how the transcriptional profile of the colonic endothelial cells is influence by colonization of gnotobiotic mice with specific bacterial strains .

2022-10-05 | GSE180907 | GEO

mRNA sequencing of small intestinal tissue of germfree mice

Project description:With this study we wanted to evaluate the impact of murine norovirus infection of germfree mice and to compare it to germfree mice which have received fecal transplants of conventional mice.

2014-11-13 | GSE60163 | GEO

Transcriptomics of the traditional Japanese medicine juzentaihoto (JTX) on germfree mice

Project description:This SuperSeries is composed of the following subset Series: GSE32083: Transcriptomics of the traditional Japanese medicine juzentaihoto (JTX) on large intestines on germfree mice GSE32084: Transcriptomics of the traditional Japanese medicine juzentaihoto (JTX) on small intestines on germfree mice Refer to individual Series

2011-09-13 | E-GEOD-32085 | biostudies-arrayexpress

Genome-wide Expression Differences in Colonocytes Isolated From Conventionally Raised or Germfree Mice

Project description:Microarray transcriptome analysis of colonocytes from conventionally raised and germfree mice. 12 samples were analyzed, with 6 germfree (GF) samples vs. 6 conventionally raised (CONV) samples.

2011-03-15 | E-GEOD-27950 | biostudies-arrayexpress

Genome-wide Expression Differences in Colonocytes Isolated From Conventionally Raised or Germfree Mice

Project description:Microarray transcriptome analysis of colonocytes from conventionally raised and germfree mice.

2011-03-15 | GSE27950 | GEO

Mouse feces metabolome conventional vs germfree

Project description:Mouse feces metabolome conventional vs germfree

| PRJEB42207 | ENA

Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.

Project description:Antibiotic-mediated microbiota destruction and the consequent loss of colonization resistance can result in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients. Clearance of VRE remains a challenging goal that, if achieved, would reduce systemic VRE infections and patient-to-patient transmission. Although obligate anaerobic commensal bacteria have been associated with colonization resistance to VRE, the specific bacterial species involved remain undefined. Herein, we demonstrate that a precisely defined consortium of commensal bacteria containing the Clostridium cluster XIVa species Blautia producta and Clostridium bolteae restores colonization resistance against VRE and clears VRE from the intestines of mice. While C. bolteae did not directly mediate VRE clearance, it enabled intestinal colonization with B. producta, which directly inhibited VRE growth. These findings suggest that therapeutic or prophylactic administration of defined bacterial consortia to individuals with compromised microbiota composition may reduce inter-patient transmission and intra-patient dissemination of highly antibiotic-resistant pathogens.

| S-EPMC5494988 | biostudies-literature

Leaf transcriptomes of Arabidopsis thaliana colonized by representative phyllosphere commensals alone and in combination with the pathogen Pseudomonas syringae DC3000

Project description:Plants are colonized by a variety of microorganisms, the plant microbiota. In the phyllosphere, the above-ground parts of plants, bacteria are the most abundant inhabitants. Most of these microorganisms are not pathogenic and the plant responses to commensals or to pathogen infection in the presence of commensals are not well understood. We report the Arabidopsis leaf transcriptome after 3 to 4 weeks of colonization by Methylobacterium extorquens PA1 and Sphingomonas melonis Fr1, representatives of two abundant genera in the phyllosphere, compared to axenic plants. In addition, we also sequenced the transcriptome of Arabidopsis 2 and 7 days after spray-infection with a low dose of P. syringae DC3000 and in combination with the commensals.

2016-06-05 | E-MTAB-4683 | biostudies-arrayexpress

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