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Gene expression level of HEI-286 Schwann cells and MiaPaCa-2 pancreatic cancer cells

ABSTRACT: Gene expression level of HEI-286 Schwann cells and MiaPaCa-2 pancreatic cancer cells

PROVIDER: PRJNA750132 | ENA |

REPOSITORIES: ENA

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Gene expression level of HEI-286 Schwann cells and MiaPaCa-2 pancreatic cancer cells

Project description:We report the transcriptome analysis of HEI-286 human Schwann cells and MiaPaCa-2 pancreatic cancer cells Nerves stimulate cancer progression for different cancer types, promoting both tumor growth and perineural invasion, a prominent process in pancreatic ductal adenocarcinoma. Yet little is known about how cells in the nerves contribute to cancer progression. Here we demonstrate that Schwann cells, the most abundant cell type in nerves, collectively function as tumor activated Schwann cell tracks (TASTs). Schwann cells in a 3D matrix organize into stellate tracks which serve as a conduit for cancer cell migration. TASTs actively promote pancreatic cancer dissemination during perineural invasion and neoneurogenesis. This key function of TASTs is induced by cancer cells triggering c-Jun activation of Schwann cells, analogous to the reprogramming that promotes nerve repair. In TASTs, dynamic Schwann cell processes wrap around and apply forces directly on cancer cells to enhance cancer motility. We define a model of cancer progression that relies upon collective Schwann cell behavior driven by c-Jun transcriptional reprogramming.

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Effect of MiaPaCa-2 cancer cells on gene expression in HEI-286 Schwann cells and c-Jun KO HEI-286 Schwan cells

Project description:We report the transcriptome analysis of control and c-Jun knock-out HEI-286 human Schwann cells in presence or absence of cancer cells

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Effect of MiaPaCa-2 cancer cells on gene expression in HEI-286 Schwann cells and c-Jun KO HEI-286 Schwan cells

Project description:Effect of MiaPaCa-2 cancer cells on gene expression in HEI-286 Schwann cells and c-Jun KO HEI-286 Schwan cells

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Expression data of MIAPaCa-2 cells transfected with NDRG1

Project description:NDRG1 functions as a metastasis suppressor in pancreatic and other cancers. To determine the molecular function of NDRG1 in MIAPaCa-2 pancreatic cancer cells, we performed a whole genome gene array analysis on these cells stably transfected with NDRG1 when compared to empty vector-transfected controls. The differentially expressed genes indetified in this microarray may represent potential molecular targets of NDRG1 in pancreatic cancer. Two separate RNA extracts of MIAPaCa-2 vector control and NDRG1 transfected cells were collected and hybridised to Affymetrix Human Genome U133 Plus 2.0 chips.

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Gene expression changes in HEI-193 (NF2-deficient Schwannoma) cells by Nf18001 or TEW7197 treatment.

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