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Haploinsufficiency of BCL6 impairs follicular T-B interactions

ABSTRACT: Haploinsufficiency of BCL6 impairs follicular T-B interactions

PROVIDER: PRJNA750642 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15264205_1.fastq.gz	Fastqsanger.gz
	SRR15264205_2.fastq.gz	Fastqsanger.gz
	SRR15264206_1.fastq.gz	Fastqsanger.gz
	SRR15264206_2.fastq.gz	Fastqsanger.gz
	SRR15264207_1.fastq.gz	Fastqsanger.gz

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Haploinsufficiency of BCL6 impairs follicular T-B interactions

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Project description:Here we show a newly identified human Innate Lymphoid Cell population present in the follicles of tonsils and lymph nodes termed follicular regulatory ILCs (ILCFR). ILCFR have a distinct phenotype and transcriptional program when compared to other defined ILCs. Surprisingly, ILCFR inhibit the ability of follicular helper T (Tfh) cells to provide B cell help. The localization of ILCFR to the germinal centers suggests these cells may interfere with germinal center B cell (GC-B) and germinal center Tfh cell (GC-Tfh) interactions through the production of transforming growth factor beta (TGF-b). Intriguingly, under conditions of impaired GC-Tfh-GC-B cell interactions, such as human immunodeficiency virus (HIV) infection, the frequency of these cells is increased. Overall, we predict a role for ILCFR in regulating GC-Tfh-GC-B cell interactions and propose they expand in chronic inflammatory conditions.

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