Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ATAC-seq in wild type and EGR2 knock-out mouse alveolar macrophages

ABSTRACT: ATAC-seq in wild type and EGR2 knock-out mouse alveolar macrophages

PROVIDER: PRJNA750658 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15295043.fastq.gz	Fastqsanger.gz
	SRR15295044.fastq.gz	Fastqsanger.gz
	SRR15295045.fastq.gz	Fastqsanger.gz
	SRR15295046.fastq.gz	Fastqsanger.gz
	SRR15295047.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Wild type and EGR2 knock-out mouse alveolar macrophages

Project description:Wild type and EGR2 knock-out mouse alveolar macrophages

| PRJNA750652 | ENA

ATAC-seq in wild type and EGR2 knock-out mouse alveolar macrophages

Project description:The alveolar macrophages (AMs) as a component of the innate immunity of the lung play important role in the elimination of inhaled microbes and harmful agents. The transcription factor EGR2 is a known marker transcription factor of AMs but its exact epigenetic and transcriptomic effects have not been examined. In our study, we performed ATAC-seq and RNA-seq in WT and EGR2 deficient alveolar macrophages to describe the mechanism of action and to predict potential direct target genes of EGR2. Clec7a is one of the targets of this transcription factor which is essential in the zymosan-induced inflammatory response. We further analyzed this process by applying in vivo mouse model. Our findings demonstrate that EGR2 is a key transcriptional activator, responsible for the intact protective program against different pathogens, especially fungi in AMs.

2024-08-29 | GSE181085 | GEO

CUT&RUN in wild type and EGR2 knock-out mouse alveolar macrophages

Project description:The alveolar macrophages (AMs) as a component of the innate immunity of the lung play important role in the elimination of inhaled microbes and harmful agents. The transcription factor EGR2 is a known marker transcription factor of AMs but its exact epigenetic and transcriptomic effects have not been examined. In our study, we performed ATAC-seq, RNA-seq, and CUT&RUN in WT and EGR2 deficient alveolar macrophages to describe the mechanism of action and to predict potential direct target genes of EGR2. Clec7a is one of the targets of this transcription factor which is essential in the zymosan-induced inflammatory response. We further analyzed this process by applying in vivo mouse model. Our findings demonstrate that EGR2 is a key transcriptional activator, responsible for the intact protective program against different pathogens, especially fungi in AMs.

2024-08-29 | GSE202858 | GEO

CUT&RUN in wild type and EGR2 knock-out mouse alveolar macrophages

Project description:CUT&RUN in wild type and EGR2 knock-out mouse alveolar macrophages

| PRJNA837570 | ENA

RNA-seq in wild type and EGR2 knock-out mouse alveolar macrophages upon vehicle and zymosan treatment

2024-08-29 | GSE181086 | GEO

RNA-seq in wild type and EGR2 knock-out mouse alveolar macrophages upon vehicle and zymosan treatment

Project description:RNA-seq in wild type and EGR2 knock-out mouse alveolar macrophages upon vehicle and zymosan treatment

| PRJNA750657 | ENA

Wild type and EGR2 knock-out mouse alveolar macrophages

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-08-31 | GSE181087 | GEO

Murine bronco alveolar lavage fluid from wild type and mannose receptor knock out mice, unchallenged and LPS challenged

Project description:A comparative analysis of the protein content in bronco alveolar lavage fluid from wild type and mannose receptor knock-out littermate mice. This includes both an unchallenged mice and mice subjected to intratracheal LPS instillation to induce injury and inflammation.

2024-04-17 | PXD049201 | Pride

Irf6 wildtype and knock out ATAC-seq

Project description:Irf6 wildtype and knock out ATAC-seq

| PRJNA524711 | ENA

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair [Alveolar macrophages]

Project description:We compare the transcriptional profile of Egr2-sufficient or Egr2-deficient airway macrophages obtained from Lyz2-Cre-Egr2-floxed mice

2021-11-19 | GSE182043 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data