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Expression data from the hippocampus of LPS induced depression mice model treated with Luteolin

ABSTRACT: Expression data from the hippocampus of LPS induced depression mice model treated with Luteolin

PROVIDER: PRJNA751403 | ENA |

REPOSITORIES: ENA

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Expression data from the hippocampus of LPS induced depression mice model treated with Luteolin

Project description:Gene expression profiling reveals a potential role of Luteolin in LPS induced depression model LPS depression induced mice were orally treated with luteolin (10 mg/kg body weight) once per day during 8 consecutive days. Microarray gene expression was conducted on mice hippocampal tissues. Two mice brains were used for each expermient . The Microarray gene expression was conducted on hipocampus from LPS depression induced mice model(LPS group), LPS depression induced mice model treated with luteolin(LPS+L group), Normal mice (PBS group) and Normal mice treated with luteolin (PBS+L).

2021-11-24 | GSE181285 | GEO

Expression data from the Neural Stem Cells (NSCs) of LPS induced depression mice model treated with Luteolin

Project description:Gene expression profiling reveals a potential role of Luteolin in LPS induced depression model LPS depression induced mice were orally treated with luteolin (10 mg/kg body weight) once per day during 8 consecutive days. Microarray gene expression was conducted for isolated mice Neural Stem Cells (NSCs) . Two mice brain were used for each expermient. The Microarray gene expression was conducted on NSCs and hipocampus from LPS depression induced depression mice (LPS group), LPS depression induced depression mice treated with luteolin(LPS+L group), Normal mice (PBS group) and Normal mice treated with luteolin (PBS+L).

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Expression data from the Neural Stem Cells (NSCs) of LPS induced depression mice model treated with Luteolin

Project description:Expression data from the Neural Stem Cells (NSCs) of LPS induced depression mice model treated with Luteolin

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Gene expression alteration in the hippocampus of depression mouse model with forced swim stress

Project description:We used microarrays to identify the gene with altered expression in the hippocampus of depression mouse model with forced swim stress campared to control mice .

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Gene expression data from the hippocampus of mice treated with oleacein in an in vivo model of depression induced by lipopolysaccharide (LPS)-mediated inflammation.

Project description:Gene expression profiling reveals potential effects of Oleacein in promoting neurogenesis and mitigating neuroinflammation in an in vivo model of depression induced by lipopolysaccharide (LPS)-mediated inflammation We evaluated the neuroprotective effects of oleacein (OC), a rare secoiridoid derivative found in extra virgin olive oil. our goal was to explore the BDNF/TrkB neurotrophic activity of OC and subsequently assess its potential for modulating neuroinflammatory response in vivo.

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Gene expression alteration in the hippocampus of depression mouse model with repeated social defeat stress

Project description:We used microarrays to identify the gene with altered expression in the hippocampus of depression mouse model with repeated social defeat stress campared to control mice.

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Transcription profiling of mouse microglia reveals luteolin has anti-inflammatory and neurotrophic effects on microglia

Project description:Our aim was to identify genes that were differentially expressed in microglia stimulated with Lipopolysaccharide, Luteolin, or both. Affymetrix microarrays were used to analyze RNA samples Experiment Overall Design: RNA from control BV-2 cells, and cells treated for 24h with LPS, Luteolin, or LPS+Luteolin was analyzed with Affymetrix GeneChip Mouse Genome 430 2.0 Arrays. Biological triplicates were analyzed for each condition

2010-01-23 | E-GEOD-18740 | biostudies-arrayexpress

Effects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics

Project description:Major depressive disorder (MDD), also known as depression, is a state characterized by low mood and aversion to activity. Platycodins Folium (PF) is the dried leaf of Platycodon grandiflorum, with anti-inflammatory and antioxidative activities. Our previous research suggested that PF was rich in flavonoids, phenols, organic acids, triterpenoid saponins, coumarins and terpenoids. This study aimed to investigate the antidepressant effect of PF using lipopolysaccharide (LPS)-induced depressive mice. Several behavior tests (sucrose preference test (SPT), forced swimming test (FST) and tail suspension test (TST)) and biochemical parameters (IL-6, TNF-α and SOD levels) were used to evaluate the antidepressive effect of PF on LPS-induced depression model. Furthermore, a UPLC-Q/TOF-MS-based metabolomics approach was applied to explore the latent mechanism of PF in attenuating depression. As a result, a total of 21 and 11 metabolites that potentially contribute to MDD progress and PF treatment were identified in serum and hippocampus, respectively. The analysis of metabolic pathways revealed that lipid metabolism, amino acid metabolism, energy metabolism, arachidonic acid metabolism, glutathione metabolism and inositol phosphate metabolism were disturbed in a model of mice undergoing MDD and PF treatment. These results help us to understand the pathogenesis of depression in depth, and to discover targets for clinical diagnosis and treatment. They also provide the possibility of developing PF into an anti-depressantive agent.

2020-06-03 | MTBLS952 | MetaboLights

Cerebrospinal Fluid Proteomics of Aging Rats with Depression

Project description:Based on the proteomics of cerebrospinal fluid, this study aimed to explore the core pathway and potential targets of luteolin treatment on late-onset depression.

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transcriptome analysis for luteolin or siVRK1 treated ovarian cancer cells

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