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3' sequencing of placenta form Mbnl2 and Mbnl3 KOs

ABSTRACT: 3' sequencing of placenta form Mbnl2 and Mbnl3 KOs

PROVIDER: PRJNA751580 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15326600.fastq.gz	Fastqsanger.gz
	SRR15326601.fastq.gz	Fastqsanger.gz
	SRR15326602.fastq.gz	Fastqsanger.gz
	SRR15326603.fastq.gz	Fastqsanger.gz
	SRR15326604.fastq.gz	Fastqsanger.gz

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3' sequencing of placenta form Mbnl2 and Mbnl3 KOs

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Placenta transcriptomics of Mbnl2 and Mbnl3 KOs (RNA-seq)

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Project description:While analyzing mRNA expression profiles of clear cell renal cell carcinoma (ccRCC) tumors, we found that the mRNAs that are bound at their 3' UTRs by muscleblind-like splicing regulator 2 (Mbnl2) and epithelial splicing regulatory protein 2 (ESRP2) are up-regulated in tumor compared to patient-matched normal tissues. Given that MBNL2 increases the stability of its targets and ESRP2 destabilizes its targets, we predicted that, in ccRCC tumors, MBNL2 activity increases, while ESRP2 activity decreases. To investigate the effect of each of these two RNA-binding proteins (RBPs) on the transcriptome of the cell, we used shRNA to knockdown MBNL2 in two different cell line models of ccRCC (786-O and A-498), and also to knockdown ESRP2 in normal primary renal proximal tubule epithelial cells (PRPTEC). RNA-seq revealed that MBNL2 knockdown partially reverses the ccRCC-associated transcriptome in ccRCC cell lines, whereas ESRP2 knockdown shifts the transcriptome of PRPTEC toward that of ccRCC.

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MBNL2 knockdown in hypoxic breast cancer cells

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Muscleblind-Like 2 mediated alternative splicing in the developing bain by mRNA sequencing

Project description:We have identified Mbnl2 mediated splicing events and mRNA expression regulation by comparing WT and Mbnl2 ?E2/?E2 mouse hippocampii using Affymetrix Mouse Exon Junction Array and mRNA sequencing. The splicing microarray data has already been submitted under GSE37908 which also includes a re-analysis of RNA-seq data. The TableS1.xls contains Splicing microarray analysis data of Mbnl2+/+ vs. MBNL2 ?E2/?E2 knockout hippocampus. The TableS2.xls files contain RNA-Seq, Gene Ontology, HITS-CLIP and CIMS summary of Mbnl2+/+ vs. MBNL2 ?E2/?E2 knockout hippocampus. The file contents are descibed in the 'TableS1_S2_readme.pdf' and data processing details are included in the 'data_processing_readme.pdf' file. 6 total samples were analyzed: brains from 3 WT and 3 MBNL2 ?E2/?E2 female mice, all 2-3 months of age.

2012-08-16 | E-GEOD-38497 | biostudies-arrayexpress

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