Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of the key epigenetic determinants of chondrocyte aging in humans

ABSTRACT: Identification of the key epigenetic determinants of chondrocyte aging in humans

PROVIDER: PRJNA751622 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15328205.fastq.gz	Fastqsanger.gz
	SRR15328206.fastq.gz	Fastqsanger.gz
	SRR15328207.fastq.gz	Fastqsanger.gz
	SRR15328362_1.fastq.gz	Fastqsanger.gz
	SRR15328362_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 31

Similar Datasets

Identification of the key epigenetic determinants of chondrocyte aging in humans (ATAC-seq)

Project description:Identification of the key epigenetic determinants of chondrocyte aging in humans (ATAC-seq)

| PRJNA751606 | ENA

Identification of the key epigenetic determinants of chondrocyte aging in humans (miRNA-seq)

Project description:Identification of the key epigenetic determinants of chondrocyte aging in humans (miRNA-seq)

| PRJNA751623 | ENA

Identification of the key epigenetic determinants of chondrocyte aging in humans (Cut&Run)

Project description:Identification of the key epigenetic determinants of chondrocyte aging in humans (Cut&Run)

| PRJNA751618 | ENA

Identification of the key epigenetic determinants of chondrocyte aging in humans (Single cell-seq)

Project description:Identification of the key epigenetic determinants of chondrocyte aging in humans (Single cell-seq)

| PRJNA751624 | ENA

Identification of the key epigenetic determinants of chondrocyte aging in humans (Cut&Run)

Project description:Articular chondrocytes undergo functional changes and their regenerative potential declines with age. Although the molecular mechanisms guiding articular cartilage aging is poorly understood, DNA methylation is known to play a mechanistic role in aging. However, our understanding of DNA methylation in chondrocyte development across human ontogeny is limited. To better understand DNA methylome changes, methylation profiling was performed in human chondrocytes. This study reveals association between methylation of specific CpG sites and chondrocyte age. We also determined the putative binding targets of STAT3, a key age-patterned TF in fetal chondrocytes and genetic ablation of STAT3 induced a global genomic hypermethylation. Moreover, an epigenetic clock built for adult human chondrocytes revealed that exposure of aged adult human chondrocytes to STAT3 agonist, decreased epigenetic age. Taken together, this work will serve as a foundation to understand development and aging of chondrocytes with a new perspective for development of rejuvenation agents for synovial joints.

2023-02-21 | GSE181351 | GEO

Identification of the key epigenetic determinants of chondrocyte aging in humans (ATAC-seq)

2023-02-21 | GSE181345 | GEO

Identification of the key epigenetic determinants of chondrocyte aging in humans (Single cell-seq)

2023-02-21 | GSE181355 | GEO

Identification of the key epigenetic determinants of chondrocyte aging in humans

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-02-21 | GSE181356 | GEO

Transcriptional landscape of aging in humans

Project description:We carried out blood transcriptome-wide association studies and replicated results to identify genes whose expression differs across the human aging spectrum. The transcriptional landscape of aging in humans

2014-06-15 | E-GEOD-58137 | biostudies-arrayexpress

The long noncoding RNA ELDR serves as an epigenetic driver in aging and injury-induced chondrocyte senescence [lncRNA]

Project description:To investigate lncRNA profile in OA patients and analyze the critical role of lncRNA in chondrocyte senescence To investigate lncRNA profile in OA patients and analyze the critical role of lncRNA in chondrocyte senescence

2021-06-20 | GSE174049 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data