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SARS-CoV-2 Neurotropism and Single Cell Responses in Brain Organoids Containing Innately Developing Microglia

ABSTRACT: SARS-CoV-2 Neurotropism and Single Cell Responses in Brain Organoids Containing Innately Developing Microglia

PROVIDER: PRJNA751930 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15340704_1.fastq.gz	Fastqsanger.gz
	SRR15340704_2.fastq.gz	Fastqsanger.gz
	SRR15340705_1.fastq.gz	Fastqsanger.gz
	SRR15340705_2.fastq.gz	Fastqsanger.gz
	SRR15340706_1.fastq.gz	Fastqsanger.gz

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SARS-CoV-2 Neurotropism and Single Cell Responses in Brain Organoids Containing Innately Developing Microglia

Project description:Here, we derive human brain organoids with innately developing microglia to investigate the cellular responses to SARS-CoV-2 infection on a single cell level. We find evidence of limited tropism to SARS-CoV-2 for all major cell types and observe extensive neuronal cell death that also include non-infected cells. Single cell transcriptome profiling reveals distinct responses in microglia and astrocytes that share features with cellular states observed in neurodegenerative diseases

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