Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome” [cross-CAD-seq]

ABSTRACT: MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome” [cross-CAD-seq]

PROVIDER: PRJNA752095 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15343166.fastq.gz	Fastqsanger.gz
	SRR15343167.fastq.gz	Fastqsanger.gz
	SRR15343168.fastq.gz	Fastqsanger.gz
	SRR15343169.fastq.gz	Fastqsanger.gz
	SRR15343170.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 13

Similar Datasets

MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome” [CAD-seq]

Project description:MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome” [CAD-seq]

| PRJNA752096 | ENA

MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome” [cross-CAD-seq]

Project description:High-intensity transcription and replication supercoil DNA to levels that can impede or halt these processes. As a potent transcription amplifier and replication accelerator, the proto-oncogene MYC must somehow manage these high levels of torsional stress. By comparing gene expression with the recruitment of topoisomerases and MYC to promoters, we surmised a direct association of MYC with Topoisomerases 1 (TOP1) and 2A (TOP2A) that was confirmed in vitro and in vivo. Beyond recruiting topoisomerases, MYC directly stimulates their activities in vitro and in vivo. We identify a MYC-nucleated “topoisome” complex that unites and increases the levels of both both TOP1 and TOP2, as well as their activities at promoters and enhancers. Whether TOP2A or TOP2B is included in the topoisome, is dictated by the presence of c-MYC or MYCN, respectively. Thus, in vivo and in vitro, MYC assembles tools that simplify DNA topology and promote genome function under high output conditions.

2021-12-09 | GSE181449 | GEO

MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome”

Project description:MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome”

| PRJNA752089 | ENA

MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome” [CAD-seq]

2021-12-09 | GSE181448 | GEO

MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome” [ChIP-seq]

Project description:MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome” [ChIP-seq]

| PRJNA752097 | ENA

MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome” [ChIP-seq]

2021-12-09 | GSE181447 | GEO

Project description:MYC assembles and stimulates topoisomerases 1 & 2 in a "topisome"

| PRJNA667145 | ENA

MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome".

Project description:High-intensity transcription and replication supercoil DNA to levels that can impede or halt these processes. As a potent transcription amplifier and replication accelerator, the proto-oncogene MYC must manage this interfering torsional stress. By comparing gene expression with the recruitment of topoisomerases and MYC to promoters, we surmised a direct association of MYC with topoisomerase 1 (TOP1) and TOP2 that was confirmed in vitro and in cells. Beyond recruiting topoisomerases, MYC directly stimulates their activities. We identify a MYC-nucleated "topoisome" complex that unites TOP1 and TOP2 and increases their levels and activities at promoters, gene bodies, and enhancers. Whether TOP2A or TOP2B is included in the topoisome is dictated by the presence of MYC versus MYCN, respectively. Thus, in vitro and in cells, MYC assembles tools that simplify DNA topology and promote genome function under high output conditions.

| S-EPMC8750365 | biostudies-literature

MYC assembles and stimulates topoisomerases 1 & 2 in a “topisome”

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-12-09 | GSE181450 | GEO

Carnobacterium maltaromaticum assembles

Project description:Carnobacterium maltaromaticum assembles

| PRJEB40278 | ENA