Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Molecular profiling of NAA25-deficient breast cancer cell line T47D

PROVIDER: PRJNA752396 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15403033_1.fastq.gz	Fastqsanger.gz
	SRR15403033_2.fastq.gz	Fastqsanger.gz
	SRR15403035_1.fastq.gz	Fastqsanger.gz
	SRR15403035_2.fastq.gz	Fastqsanger.gz
	SRR15403037_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Project description:Breast cancer cell line T47D sequencing

| PRJNA1170264 | ENA

Gene expression changes in different clones of SAMHD1 knock-out (KO) cells grown in 3D structures (spheroids)

Project description:To explore the mechanisms underlying SAMHD1 effect on breast cancer prognosis whole transciptome profiling was performed in WT and in different clones of SAMHD1-KO breast cancer cell line (T47D cells) grown in spheroids. Spheroids represents better the tumor microenvironment.

2023-12-05 | GSE224678 | GEO

Study of SPEN overexpression in T47D cells. (2)

Project description:We investigated the functions/pathways affected by SPEN in breast cancer by global expression profiling in a cell model, where the human breast cancer cell line, T47D, were transfected with an expression vector coding for SPEN.

2015-10-21 | E-MTAB-2182 | biostudies-arrayexpress

Gene expression changes in different clones of SAMHD1 knock-out (KO) cells

Project description:To investigate the signalling pathways affected by SAMHD1 depletion, whole transciptome profiling was performed in WT and in different clones of SAMHD1-KO breast cancer cell line (T47D cells)

2023-02-07 | GSE215309 | GEO

aCGH hybridization of breast cancer cell line T47D

Project description:An array CGH hybridization of breast cancer cell line T47D compared against a normal human female reference.

2010-06-25 | GSE22547 | GEO

Anti-cancer effects of 7-oxabicyclo[2.2.1]heptene sulfonamide (OBHSA) derivative 17e on gene expression of breast cancer T47D cells

Project description:To investigate the anti-cancer effects of PROTAC-like OBHSA derivative 17e, we exposed estrogen receptor alpha positive (ERα+) breast cancer cell line T47D to compound 17e at 10 μM for 12 hours . We then performed gene expression profiling analysis using data obtained from RNA-seq of T47D cells treated with DMSO or 17e (10 μM) in three replicates.

2024-06-18 | GSE210169 | GEO

Homo sapiens

Project description:aCGH hybridization of breast cancer cell line T47D

| PRJNA128175 | ENA

T47D Breast cancer cell line ChIP-seq data

Project description:T47D Breast cancer cell line ChIP-seq data

| PRJNA415426 | ENA

RHBDD2 silencing and gene expression profiling of breast cancer cells

Project description:In previous studies, we identified a distantly related rhomboid homologue gene known as RHBDD2 (Rhomboid domain containing 2) to be markedly overexpressed in the advanced stages of the breast and colorectal cancer diseases. In order to identify RHBDD2 modulated pathways, we analyzed two breast cancer cell lines (MCF7 and T47D) from control and RHBDD2-siRNA transient gene silencing followed by gene expression profiling analysis using the whole genome Toray 3D-GeneTM Human Oligo Chip. Statistical analysis of the Toray's 3D gene expression profiling data identified 566 commonly differentially expressed genes in association to the RHBDD2 knockdown in both breast cancer cell lines. Among the statistically significant over-represented biological process, we found the apoptosis, cell cycle and response to DNA damage process related genes. In addition, categories of genes found in the ubiquitin-proteasome and oxidative phosphorylation were also highly enriched related genes in the commonly deregulated gene list. We further used a lentivirus-based system (shRNA-pLKO.1) for stable silencing of RHBDD2 mRNA in the T47D breast cancer cell line. Using a staurosporine-induced apoptosis model, we demonstrate that RHBDD2 abrogation resulted in an apoptosis-resistant phenotype of T47D breast cancer cell line. These data are in line with a recent study, suggesting that RHBDD2 expression could be up-modulated in response to 5FU-induced apoptosis in colorectal cancer cells. Taken together, these data suggest that RHBDD2 could be involved in the modulation of the programmed cell death in cancer cells. In order to analyze differential gene expression profiling of RHBDD2 silencing and control cells, total RNA was isolated from replicate experiments from two breast cancer cell lines (MCF7 and T47D) derived from the negative control-siRNA and the RHBDD2-siRNA treatments in duplicate experiments.

2013-04-10 | E-GEOD-43015 | biostudies-arrayexpress

Next Generation Sequencing Facilitates Quantitative Analysis of human breast cancer cell T47D and T47D-TR Transcriptomes

Project description:To gain new insight into the resistance to hormonal therapy in breast cancer, we generated a tamoxifen-resistant human breast cancer cell line T47D-TR by exposing estrogen-sensitive cell line T47D to increasing concentrations of 4-hydroxy tamoxifen (4-OHT) and identified its resistance with different ways. What we interested is the underlying mechanisms of breast cancer tamoxifen resistance which was not reported yet.Here, we detect the RNA sequence of both the two cell lines hoping to find some evidence.

2020-01-28 | GSE125738 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data