Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Pathway Preferential Estrogens prevent hepatosteatosis due to ovariectomy and high-fat diets

ABSTRACT: Pathway Preferential Estrogens prevent hepatosteatosis due to ovariectomy and high-fat diets

PROVIDER: PRJNA753466 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15403700.fastq.gz	Fastqsanger.gz
	SRR15403701.fastq.gz	Fastqsanger.gz
	SRR15403702.fastq.gz	Fastqsanger.gz
	SRR15403703.fastq.gz	Fastqsanger.gz
	SRR15403704.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Pathway Preferential Estrogens prevent hepatosteatosis due to ovariectomy and high-fat diets

Project description:Pathway preferential estrogen 1 (PaPE-1) is a novel estrogen receptor ligand that has been shown to favorably affect metabolic tissues without adverse effects on reproductive tissues. In this study, we have examined the effects of PaPE-1 on metabolic health, in particular, examin-ing its effects on the liver transcriptome and on plasma metabolites in two different mouse mod-els: diet-induced obesity (DIO) and leptin-deficient (ob/ob) mice. PaPE-1 significantly decreased liver weight and lipid accumulation in both DIO and ob/ob models and lowered the expression of genes associated with fatty acid metabolism and collagen deposition. Overall, our findings support a beneficial metabolic role for PaPE-1 and suggest that PaPE-1 may protect postmenopausal women from fatty liver disease without increasing reproductive cancer risk.

2024-08-10 | GSE181780 | GEO

Development of Pathway Preferential Estrogens Affording Beneficial Metabolic and Vascular Actions without Reproductive Tissue Stimulation in Mice

Project description:There is great medical need for estrogens having favorable pharmacological profiles, supporting desirable activities for menopausal women such as metabolic and vascular protection but lacking stimulatory activities on the breast or uterus. Here, we report the development of structurally novel estrogens with favorable target tissue-selective estrogenic activity. Through a process of structural alteration of the hormone estradiol that preserves essential chemical and physical features of estradiol but greatly moderates its binding affinity for the estrogen receptors (ERs), we obtained Pathway Preferential Estrogens (PaPEs) capable of having interaction with ER that is sufficient to activate the extranuclear-initiated signaling pathway preferentially over the direct nuclear-initiated pathway. PaPE modulate a pattern of gene regulation and cellular and biological processes that result in essentially no stimulation of reproductive and mammary tissues and breast cancer cells, but have a favorable pattern of activity on metabolic tissues and the vasculature. The structural permutation process represents a novel approach to govern the balance in utilization of extranuclear vs. nuclear pathways of ER action to obtain tissue-selective/non-nuclear pathway-preferential estrogens, which should prove to be beneficial for postmenopausal hormone replacement. The approach may also have broad applicability for other members of the nuclear hormone receptor superfamily. 24 samples; inhibitor and time course experiments

2016-07-20 | E-GEOD-73663 | biostudies-arrayexpress

Development of Pathway Preferential Estrogens Affording Beneficial Metabolic and Vascular Actions without Reproductive Tissue Stimulation in Mice

2016-07-20 | GSE73663 | GEO

ovariectomy of mouse contents

Project description:ovariectomy of mouse contents Raw sequence reads

| PRJNA1031711 | ENA

microRNA expression in sham and ovariectomy (OVX) mice femur tissue

Project description:To search for the role of microRNAs in postmenopausal osteoporosis, we used an experimental ovariectomized (OVX) mice moldel. We operated ovariectomy in 3-month-old C57BL/6 mice and collected the femurs after 6months to perform miRNA microarray analysis to identify dysregulated microRNAs.

2018-01-27 | GSE109705 | GEO

Gene expression changes in femur tissues of ovariectomy-induced osteoporosis rats

Project description:To study the differentially expressed genes in postmenopausal osteoporosis , a postmenopausal osteoporosis rat model were constructed by bilateral ovariectomy. We then performed gene expression profiling analysis using data obtained from RNA-seq of the rat femur tissues.

2022-06-24 | GSE201674 | GEO

Uterine Transcriptional Profile Following Treatment with Estradiol or Synthetic Estrogens Diethylstilbestrol and Propyl Pyrazole Triol

Project description:Transcriptional responses in ovariectomized mouse uterine tissue to estradiol (E2) and diethylstilbestrol (DES), known long-acting estrogens, and propyl pyrazole triol (PPT), an ER-alpha selective estrogen, were profiled. Profiles were used together with those from other estrogens to derive a biomarker panel.

2015-10-01 | GSE61921 | GEO

Blueberry Diets during Early Development Only Is Sufficient to Prevent Senescence of Osteoblasts and Bone Loss in Adulthood

Project description:Appropriate nutrition during early development is essential for optimal bone mass accretion; however, linkage between early nutrition, childhood bone mass and prevention of bone loss later in life has not been extensively studied. In this report, we have demonstrated several fundamental issues in the field. 1) A significant prevention of ovariectomy (OVX) -induced bone loss from adult rats can occur with only 14 days consumption of a blueberry-containing diet immediately prior to puberty. 2) The molecular mechanisms underlying these effects involve increased myosin production and preserved a shuttle for transcription factors such as Runx2 from cytoplasm to nucleolus which stimulates osteoblast differentiation and reduces mesenchymal stromal cell senescence. 3) The effects of blueberry diet on preserving fidelity of osteoblast differentiation also overcome reduced osteoblast differentiation and activity due to OVX-induced degradation of collagen matrix. Bone quality was compared among casein control diet sham operated, casein diet ovariectomized, long term BB diet ovariectomized, and short term BB diet ovariectomized female rats

2012-06-30 | E-GEOD-30081 | biostudies-arrayexpress

Liver proteomics of the HMDP - Hepatosteatosis underlies several diseases including type 2 diabetes, cardiovascular disease and liver disease

Project description:Hepatosteatosis underlies several diseases including type 2 diabetes, cardiovascular disease and liver disease. Unfortunately, our understanding of the contributing pathways that initiate and advance hepatosteatosis to subsequent complications is still poorly understood. Here, we take advantage of recent developments in “omics” technologies to perform high resolution proteomics (>5000 proteins) and quantitative lipidomics (>300 lipids) on livers from 107 genetically diverse inbred mouse strains from the hybrid mouse diversity panel. Integration of these data allowed us to define novel regulators of lipid metabolism in the liver.

2019-11-01 | PXD007281 | Pride

Blueberry Diets during Early Development Only Is Sufficient to Prevent Senescence of Osteoblasts and Bone Loss in Adulthood

2012-07-01 | GSE30081 | GEO