Project description:Late-onset Alzheimer’s disease (LOAD) is the most common form of AD. However, modeling sporadic LOAD, without clear genetic predispositions, to capture hallmark neuronal pathologies such as extracellular amyloid-β (Aβ) plaque deposition, intracellular tau tangles, and neuronal loss, remains an unmet need. Here, we demonstrate that neurons generated by microRNA-based direct reprogramming of fibroblasts from patients affected by autosomal dominant AD (ADAD) and LOAD in a three-dimensional (3D) environment, effectively recapitulate key neuropathological features of AD without additional cellular or genetic insults. These LOAD neurons exhibit Aβ-dependent neurodegeneration, as treatment with β- or γ-secretase inhibitors before (but not subsequent to) Aβ deposit formation mitigated neuronal death. Moreover, inhibiting age-associated retrotransposable elements (RTEs) in LOAD neurons reduced both Ab deposition and neurodegeneration. Our study underscores the efficacy of modeling late-onset neuropathology of LOAD through high-efficiency microRNA-based neuronal reprogramming.

2024-08-05 | GSE252932 | GEO

Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming II

2024-08-05 | GSE253174 | GEO

Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming III

2024-08-05 | GSE267613 | GEO

Transcriptomics profiling of Alzheimer's disease reveal novel molecular targets

Project description:Our data provide a comprehensive list of transcriptomics alterations and warrant holistic approach including both coding and non-coding RNAs in functional studies aimed to understand the pathophysiology of LOAD We performed directional RNA sequencing on high quality RNA samples extracted from hippocampi of 4 late onset Alzheimer's diseas (LOAD) and 4 age-matched controls.

2015-04-01 | E-GEOD-67333 | biostudies-arrayexpress

Cerebrospinal fluid proteomic profiling reflects biological heterogeneity of early-onset Alzheimer's disease dementia

Project description:Cerebrospinal fluid proteomic profiling reflects biological heterogeneity of early-onset Alzheimer's disease dementia from The First Affiliated Hospital of USTC

2023-02-16 | PXD040216 |

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