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The small and large intestine contain transcriptionally related mesenchymal subsets that derive from embryonic Gli1+ mesothelial cells

ABSTRACT: The small and large intestine contain transcriptionally related mesenchymal subsets that derive from embryonic Gli1+ mesothelial cells

PROVIDER: PRJNA755259 | ENA |

REPOSITORIES: ENA

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The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [scRNA-Seq]

Project description:The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [scRNA-Seq]

| PRJNA753071 | ENA

The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [adult scRNA-Seq]

Project description:The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [adult scRNA-Seq]

| PRJNA749303 | ENA

The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [E12.5 scRNA-Seq]

Project description:The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [E12.5 scRNA-Seq]

| PRJNA754169 | ENA

The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [adult bulk RNA-Seq]

Project description:The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [adult bulk RNA-Seq]

| PRJNA755257 | ENA

The small and large intestine contain transcriptionally related mesenchymal subsets that derive from embryonic Gli1+ mesothelial cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-03-17 | GSE182176 | GEO

The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [scRNA-Seq]

Project description:One round of grafted SI and LI presorted YFP+ mesenchymal stromal cells were subjected to scRNA-seq.

2023-03-17 | GSE181707 | GEO

The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [E12.5 scRNA-Seq]

Project description:Two rounds of embryonic (E12.5) small and large intestinal pre-sorted intestinal mesenchymal stromal cells were subjected for scRNA-seq.

2023-03-17 | GSE182005 | GEO

The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [adult scRNA-Seq]

Project description:Two rounds of small and large intestinal lamina propria pre-sorted intestinal mesenchymal stromal cells were subjected for scRNA-seq.

2023-03-17 | GSE180735 | GEO

The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells [adult bulk RNA-Seq]

Project description:Sorted populations of stroma cells from the small and large intestinal lamina propria. Each population has 3 replicates per tissue and were individually subjected to RNA-seq.

2023-03-17 | GSE182175 | GEO

The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1<sup>+</sup> precursors.

Project description:The intestinal lamina propria contains a diverse network of fibroblasts that provide key support functions to cells within their local environment. Despite this, our understanding of the diversity, location and ontogeny of fibroblasts within and along the length of the intestine remains incomplete. Here we show that the small and large intestinal lamina propria contain similar fibroblast subsets that locate in specific anatomical niches. Nevertheless, we find that the transcriptional profile of similar fibroblast subsets differs markedly between the small intestine and colon suggesting region specific functions. We perform in vivo transplantation and lineage-tracing experiments to demonstrate that adult intestinal fibroblast subsets, smooth muscle cells and pericytes derive from Gli1-expressing precursors present in embryonic day 12.5 intestine. Trajectory analysis of single cell RNA-seq datasets of E12.5 and adult mesenchymal cells suggest that adult smooth muscle cells and fibroblasts derive from distinct embryonic intermediates and that adult fibroblast subsets develop in a linear trajectory from CD81+ fibroblasts. Finally, we provide evidence that colonic subepithelial PDGFRαhi fibroblasts comprise several functionally distinct populations that originate from an Fgfr2-expressing fibroblast intermediate. Our results provide insights into intestinal stromal cell diversity, location, function, and ontogeny, with implications for intestinal development and homeostasis.

| S-EPMC10121680 | biostudies-literature

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