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Single cell analysis of meningeal ectopic lymphoid tissue and secondary lymphoid tissues in a spontaneous EAE model

ABSTRACT: Single cell analysis of meningeal ectopic lymphoid tissue and secondary lymphoid tissues in a spontaneous EAE model

PROVIDER: PRJNA757745 | ENA |

REPOSITORIES: ENA

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Single cell analysis of meningeal ectopic lymphoid tissue and secondary lymphoid tissues in a spontaneous EAE model

Project description:Objective: To investigate how similar meningeal ectopic lymhpoid tissue (mELT) is to secondary lymphoid tissues and find unique features of mELT that could allow therapeutic targetting of mELT specifically. Methods: We utilized a spontaneous chronic experimental autoimmune encephalomyelitis (EAE) model of mice with mutant T and B cell receptors specific for myelin oligodendrocyte glycoprotein (MOG), which develop meningeal inflammatory infiltrates resembling those described in Multiple Sclerosis (MS). We identified differences in cell composition and gene expression between mELT and secondary lymphoid tissues (lumbar and inguinal lymph nodes and the spleen) using single cell sequencing.

2023-11-01 | GSE182774 | GEO

Single cell analysis of meningeal ectopic lymphoid tissue and lumbar lymph nodes in a spontaneous EAE model

2023-11-01 | GSE181526 | GEO

Effect of anti-CD20 treatment on the composition and gene expression of meningeal ectopic lymphoid tissue and CSFin a spontaneous EAE model, using single cell gene expression .

Project description:Objective: To investigate how anti-CD20 B cell-depleting monoclonal antibodies (ɑCD20 mAb) alter the composition and gene expression of immune cells in meningeal ectopic lymphoid tissue (mELT) and the CSF in a murine model of Multiple Sclerosis (MS). Methods: We utilized a spontaneous chronic experimental autoimmune encephalomyelitis (EAE) model of mice with mutant T and B cell receptors specific for myelin oligodendrocyte glycoprotein (MOG), which develop meningeal inflammatory infiltrates resembling those described in Multiple Sclerosis (MS). We studied the changes in cell composition and gene expression after anti-CD20 treatment in mELT and CSF.

2023-11-01 | GSE181506 | GEO

Single cell analysis of meningeal ectopic lymphoid tissue and lumbar lymph nodes in a spontaneous EAE model

Project description:Single cell analysis of meningeal ectopic lymphoid tissue and lumbar lymph nodes in a spontaneous EAE model

| PRJNA752357 | ENA

Effect of anti-CD20 treatment on the composition and gene expression of meningeal ectopic lymphoid tissue and CSFin a spontaneous EAE model, using single cell gene expression .

Project description:Effect of anti-CD20 treatment on the composition and gene expression of meningeal ectopic lymphoid tissue and CSFin a spontaneous EAE model, using single cell gene expression .

| PRJNA752282 | ENA

Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation

Project description:Ectopic lymphoid tissue containing B cells forms in the meninges at late stages of human multiple sclerosis (MS) and when neuroinflammation is induced by interleukin (IL)-17 producing T helper (Th17) cells in rodents. B cell differentiation and the subsequent release of class-switched immunoglobulins have been speculated to occur in the meninges, but the exact cellular composition and underlying mechanisms of meningeal-dominated inflammation remain unknown. Here, we performed in depth characterization of meningeal vs. parenchymal Th17-induced rodent neuroinflammation. The most pronounced cellular and transcriptional differences between these compartments was the localization of B cells exhibiting a follicular phenotype exclusively to the meninges. Correspondingly, meningeal but not parenchymal Th17 cells, acquired a B cell-supporting phenotype and resided in close contact with B cells. This preferential B cell tropism for the meninges and the formation of meningeal ectopic lymphoid tissue was partially dependent on the expression of the transcription factor Bcl6 in Th17 cells, that is required in other T cell lineages to induce isotype class-switching in B cells. A function of Bcl6 in Th17 cells was only detected in vivo and was reflected by the induction of B cell-supporting cytokines, the appearance of follicular B cells in the meninges, and of immunoglobulin class-switching in the CSF. We, thus, identify the induction of a B cell-supporting meningeal microenvironment by Bcl6 in Th17 cells as a novel mechanism controlling compartment-specificity in neuroinflammation.

2021-07-30 | GSE178085 | GEO

Venous plexus-associated lymphoid hubs support meningeal humoral immunity

Project description:Venous plexus-associated lymphoid hubs support meningeal humoral immunity

| PRJNA1064095 | ENA

Venous plexus-associated lymphoid hubs support meningeal humoral immunity

Project description:Venous plexus-associated lymphoid hubs support meningeal humoral immunity

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Ectopic lymphoid structures in the aged lacrimal glands

Project description:Ectopic lymphoid structures in the aged lacrimal glands

| PRJNA931932 | ENA

Meningeal natural killer cells and innate lymphoid cells 1 tune anxiety and memory via interferon-γ and acetylcholine

Project description:The mechanisms of communication between the brain and the neighboring meningeal immune cells are still unclear. Here we characterized the resident group 1 innate lymphoid cells in the meninges of adult mice, and identified ILC1/NK cell-derived interferon- and acetylcholine as mediators involved in the modulation of brain circuitries underlying anxiety-like behavior and memory. This discloses a new meningeal-to-brain communication mechanism that modulates brain functions under physiological conditions.

2023-05-05 | GSE212089 | GEO

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