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Genomic and Clinical Findings in Myeloid Neoplasms with PDGFRB Rearrangement

ABSTRACT: Genomic and Clinical Findings in Myeloid Neoplasms with PDGFRB Rearrangement

PROVIDER: PRJNA757976 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15618900_1.fastq.gz	Fastqsanger.gz
	SRR15618900_2.fastq.gz	Fastqsanger.gz
	SRR15618901_1.fastq.gz	Fastqsanger.gz
	SRR15618901_2.fastq.gz	Fastqsanger.gz
	SRR15618902_1.fastq.gz	Fastqsanger.gz

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Genomic and Clinical Findings in Myeloid Neoplasms with PDGFRB Rearrangement [seq]

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Genomic and Clinical Findings in Myeloid Neoplasms with PDGFRB Rearrangement [seq]

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Genomic and clinical findings in myeloid neoplasms with PDGFRB rearrangement.

Project description:Platelet-derived growth factor receptor B (PDGFRB) gene rearrangements define a unique subgroup of myeloid and lymphoid neoplasms frequently associated with eosinophilia and characterized by high sensitivity to tyrosine kinase inhibition. To date, various PDGFRB/5q32 rearrangements, involving at least 40 fusion partners, have been reported. However, information on genomic and clinical features accompanying rearrangements of PDGFRB is still scarce. Here, we characterized a series of 14 cases with a myeloid neoplasm using cytogenetic, single nucleotide polymorphism array, and next-generation sequencing. We identified nine PDGFRB translocation partners, including the KAZN gene at 1p36.21 as a novel partner in a previously undescribed t(1;5)(p36;q33) chromosome change. In all cases, the PDGFRB recombination was the sole cytogenetic abnormality underlying the phenotype. Acquired somatic variants were mainly found in clinically aggressive diseases and involved epigenetic genes (TET2, DNMT3A, ASXL1), transcription factors (RUNX1 and CEBPA), and signaling modulators (HRAS). By using both cytogenetic and nested PCR monitoring to evaluate response to imatinib, we found that, in non-AML cases, a low dosage (100-200 mg) is sufficient to induce and maintain longstanding hematological, cytogenetic, and molecular remissions.

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Affymetrix SNP array data for Myeloid Neoplasms with PDGFRB Rearrangement

Project description:Here we characterized a series of cases with myeloid neoplasms using cytogenetic, single nucleotide polymorphism array, and next generation sequencing.

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Nanopore Sequencing for the screening of Myeloid and Lymphoid neoplasms with eosinophilia and rearrangement of PDGFRa, PDGFRb, FGFR1 or PCM1-JAK2.

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Project description:The EBF1-PDGFRB gene fusion accounts for <1% B-cell precursor acute lymphoblastic leukaemia and occurs within the Philadelphia-like ALL subtype. We performed Affymetrix SNP 6.0 array was undertaken patients who tested positive for EBF1-PDGFRB rearrangement by FISH and/or RT-PCR. We performed Affymetrix SNP 6.0 array on genomic DNA extracted from bone marrow samples taken at diagnosis in 9 patients, at relapse in one patient and at remission in one patient.

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