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A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis

ABSTRACT: A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis

PROVIDER: PRJNA758929 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15669469.fastq.gz	Fastqsanger.gz
	SRR15669470.fastq.gz	Fastqsanger.gz
	SRR15669471.fastq.gz	Fastqsanger.gz

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A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis

Project description:A new population of dysfunctional astrocytes in the aging mouse hippocampus called autophagy-dysregulated astrocytes (APDAs) show impaired protein homeostasis and defective regulation of synapse formation and elimination and appear early in a mouse model of Alzheimer’s disease.

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Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway ( nascent RNA-Seq )

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