Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Vaginal microbiota of pregnant women with inflammatory bowel disease

PROVIDER: PRJNA759867 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15700400.fastq.gz	Fastqsanger.gz
	SRR15700401.fastq.gz	Fastqsanger.gz
	SRR15700402.fastq.gz	Fastqsanger.gz
	SRR15700403.fastq.gz	Fastqsanger.gz
	SRR15700404.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 80

Similar Datasets

human vaginal metagenome

Project description:Vaginal microbiota of women with vs. without inflammatory bowel disease

| PRJNA849603 | ENA

Profiling of the vaginal microbiota of pregnant women during different trimesters and at sampling sites

Project description:Vaginal microbiota of pregnant women

| PRJEB4989 | ENA

vaginal microbiota of pregnant women

Project description:vaginal microbiota of pregnant women

| PRJEB10913 | ENA

Project description:Vaginal microbiota of pregnant women with IBD

| PRJNA915128 | ENA

vaginal microbiome for pregnant women

Project description:vaginal microbiome for pregnant women

| PRJNA488871 | ENA

Project description:Vaginal microbiome of Korean pregnant women

| PRJNA874481 | ENA

human metagenome

Project description:Vaginal Microbial Profiles of Pregnant Women

| PRJNA521059 | ENA

human vaginal metagenome

Project description:Vaginal microbiome of healthy pregnant women

| PRJNA317763 | ENA

Role of the Cervico-Vaginal Microbiome in Spontaneous Preterm Birth

Project description:<p>Preterm birth is the leading cause of neonatal morbidity and mortality. A failure to predict and understand the causes of preterm birth have limited effective interventions and therapeutics. From a cohort of 2,000 pregnant women, we performed a nested case control study on 107 well-phenotyped cases of spontaneous preterm birth (sPTB) and 432 women delivering at term. Modern and innovative Bayesian modeling of vaginal microbiota identified features of these communities associated with PTB. Seven bacterial taxa were shown to have relative abundances significantly associated with an increased risk of sPTB, with a stronger effect in African American women. However, higher vaginal levels of β-defensins significantly decreased the risk of sPTB associated with the vaginal microbiota in an ethnicity-dependent manner. These findings hold promise for the development of novel diagnostics that could more accurately identify women at risk for sPTB early in pregnancy and offer new therapeutic strategies that would include immune modulators and microbiome-based therapeutics to reduce this significant health burden.</p>

| phs001739 | dbGaP

Effect of L. rhamnosus GR-1 and L. reuteri RC-14 on host responses in a trial of post-menopausal women

Project description:A lactobacilli dominated microbiota in most pre and post-menopausal women is an indicator of vaginal health. A Nugent scoring system serves as a proxy for determining the ratio of lactobacilli to other vaginal inhabitants where a high score usually represents a diseased state, whilst an intermediate score represents a warning zone. The objective of this double blinded, placebo-controlled crossover study was to evaluate in 14 post-menopausal women with an intermediate score, the effect of vaginal administration of probiotic L. rhamnosus GR-1 and L. reuteri RC-14 on the microbiota and host response. The probiotic treatment did not result in changes to clinical parameters such as dryness, irritation and comfort, compared to when placebo was applied. Analysis using 16S rRNA sequencing and metabolomics profiling revealed that the proportional abundance of Lactobacillus was increased following probiotic administration as compared to placebo, which was weakly associated with an increase in lactate levels. Analysis of host responses by microarray showed the probiotics had an immune-modulatory response and multiplex cytokine analysis showed up-regulation of IL-5. This is the first study to use an interactomic approach for the study of vaginal probiotic administration in post-menopausal women. It shows that in some cases multifaceted approaches are required to detect the subtle trigger molecular changes induced by the host to instillation of probiotic strains. A total of 35 total RNA samples extracted from vaginal brushes were analyzed on Affymetrix Gene 2.0 ST arrays from 14 Participants collected over multiple visits including administration of either a probiotic supplement or placebo control.

2014-07-20 | E-GEOD-54363 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data