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Characterisation of a hybrid histidine kinase controlling acetate metabolism in Acinetobacter baumannii

ABSTRACT: Characterisation of a hybrid histidine kinase controlling acetate metabolism in Acinetobacter baumannii

PROVIDER: PRJNA760304 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15711589_1.fastq.gz	Fastqsanger.gz
	SRR15711589_2.fastq.gz	Fastqsanger.gz
	SRR15711590_1.fastq.gz	Fastqsanger.gz
	SRR15711590_2.fastq.gz	Fastqsanger.gz
	SRR15711591_1.fastq.gz	Fastqsanger.gz

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Characterisation of a hybrid histidine kinase controlling acetate metabolism in Acinetobacter baumannii

Project description:RNA sequencing transcriptomics was performed on a highly multidrug resistant A. baumannii strain belonging to international clone I, AB5075_UW and a transposon insertion inactivated mutant of ABUW_0182 (acmS), which encodes a hybrid histidine kinase.Transcriptomics suggests that AcmS controls expression of the genes involved in short-chain fatty acid metabolism in A. baumannii. Biophysical analyses showed ABUW_0182 binds acetic and propionic acid with affinities in a low micromolar range, suggesting they represent the physiological ligands for this hybrid histidine kinase system.

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