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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

ABSTRACT: Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

PROVIDER: PRJNA760468 | ENA |

REPOSITORIES: ENA

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq FSC)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

2023-12-31 | GSE183389 | GEO

Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq DC)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (scRNA-Seq)

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq DC)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq DC)

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq FSC)

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (scRNA-Seq)

Project description:Gut-draining mesenteric and celiac lymph nodes (mLNs and celLNs) critically contribute to peripheral tolerance towards food and microbial antigens by efficiently supporting the de novo induction of regulatory T cells (Tregs). These tolerogenic properties of mLNs and celLNs are stably imprinted within stromal cells (SCs) by microbial signals and vitamin A (VA), respectively. In the present study, we demonstrated that a transient neonatal gastrointestinal infection long-lastingly affects the functionality of celLN by permanently abrogating the efficient Treg-inducing capacity of celLN SCs. The neonatal infections durably shifted the heterogeneity of celLN SCs with permanently altered expression of genes involved in chemotaxis and inflammatory responses, resulting in a lastingly skewed dendritic cell (DC) composition. Mechanistically, transiently reduced VA levels caused the long-lastingly impaired celLN function, which could be rescued by an early-life VA supplementation. Together, our data highlight the therapeutic potential of VA treatment post gastrointestinal infections in infants.

2023-12-31 | GSE183390 | GEO

Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-31 | GSE183391 | GEO

Lymph node myeloid cells

Project description:Lymph node myeloid cells

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Matrix Remodelling during Lymph Node Expansion

Project description:In this study we focussed our investigations on ECM remodelling by FRCs during lymph node (LN) expansion, and the interconnection between the cellular and ECM components of the conduit network. We demonstrate a loss of ECM components of the conduit during acute LN expansion

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Gene expression signatures for B cells from tumor draining lymph node and normal lymph node

Project description:To determine the different gene signatures between B lymphocytes from tumor draining lymph node (DLN) and normal lymph node (NLN), we have employed gene microarray as a discovery platform to identify gene signatures of tumor-educated B cells in DLN from tumor-bearing mice, taking NLN from normal mice as a control. We subcutaneously inoculated Balb/c mice with breast cancer cell line 4T1. Two weeks later, DLN was harvest and B cells were purified as descript in “treatment protocol”. From gene microarray, we found that B cells in DLN showed quite different transcript profiles from that in NLN.

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