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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq DC)

ABSTRACT: Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq DC)

PROVIDER: PRJNA760475 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15712800.fastq.gz	Fastqsanger.gz
	SRR15712801.fastq.gz	Fastqsanger.gz
	SRR15712802.fastq.gz	Fastqsanger.gz
	SRR15712803.fastq.gz	Fastqsanger.gz
	SRR15712804.fastq.gz	Fastqsanger.gz

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq DC)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

2023-12-31 | GSE183388 | GEO

Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq FSC)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (scRNA-Seq)

Project description:Gut-draining mesenteric and celiac lymph nodes (mLNs and celLNs) critically contribute to peripheral tolerance towards food and microbial antigens by efficiently supporting the de novo induction of regulatory T cells (Tregs). These tolerogenic properties of mLNs and celLNs are stably imprinted within stromal cells (SCs) by microbial signals and vitamin A (VA), respectively. In the present study, we demonstrated that a transient neonatal gastrointestinal infection long-lastingly affects the functionality of celLN by permanently abrogating the efficient Treg-inducing capacity of celLN SCs. The neonatal infections durably shifted the heterogeneity of celLN SCs with permanently altered expression of genes involved in chemotaxis and inflammatory responses, resulting in a lastingly skewed dendritic cell (DC) composition. Mechanistically, transiently reduced VA levels caused the long-lastingly impaired celLN function, which could be rescued by an early-life VA supplementation. Together, our data highlight the therapeutic potential of VA treatment post gastrointestinal infections in infants.

2023-12-31 | GSE183390 | GEO

Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (scRNA-Seq)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (scRNA-Seq)

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq FSC)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq FSC)

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

Project description:This SuperSeries is composed of the SubSeries listed below.