Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

PRMT5 Promotes Progression of Chronic Lymphocytic Leukemia

ABSTRACT: PRMT5 Promotes Progression of Chronic Lymphocytic Leukemia

PROVIDER: PRJNA760770 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19586135_1.fastq.gz	Fastqsanger.gz
	SRR19586135_2.fastq.gz	Fastqsanger.gz
	SRR19586136_1.fastq.gz	Fastqsanger.gz
	SRR19586136_2.fastq.gz	Fastqsanger.gz
	SRR19586137_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

PRMT5 Promotes Progression of Chronic Lymphocytic Leukemia [3_vs_6_mo_RNA-Seq]

Project description:Purpose: Richter’s Transformation (RT) is a poorly understood and often fatal progression of chronic lymphocytic leukemia (CLL) manifesting histologically as diffuse large B-cell lymphoma. PRMT5 is implicated in lymphomagenesis, but its role in CLL or RT progression is unknown. We demonstrate herein that tumors uniformly overexpress PRMT5 in patients with progression to RT. Furthermore, mice with B-specific overexpression of hPRMT5 developed a B-lymphoid expansion with increased risk of death, and Eµ-PRMT5/TCL1 double transgenic mice uniformly developed a highly aggressive disease that histologically resembles RT; where large-scale transcriptional profiling identified unique oncogenic pathways that mediate PRMT5-driven disease progression. Taken together, the discovery that PRMT5 drives oncogenic pathways promoting RT provides a compelling rationale for clinical investigation of PRMT5 inhibitors such as PRT382 in aggressive CLL/RT cases

2022-12-07 | GSE183427 | GEO

PRMT5 Promotes Progression of Chronic Lymphocytic Leukemia [scRNA-Seq]

2022-12-07 | GSE183426 | GEO

PRMT5 Promotes Progression of Chronic Lymphocytic Leukemia [ATAC-Seq]

2022-12-07 | GSE183429 | GEO

PRMT5 Promotes Progression of Chronic Lymphocytic Leukemia [scRNA-Seq]

Project description:PRMT5 Promotes Progression of Chronic Lymphocytic Leukemia [scRNA-Seq]

| PRJNA760768 | ENA

PRMT5 Promotes Progression of Chronic Lymphocytic Leukemia [ATAC-Seq]

Project description:PRMT5 Promotes Progression of Chronic Lymphocytic Leukemia [ATAC-Seq]

| PRJNA760774 | ENA

PRMT5 Promotes Progression of Chronic Lymphocytic Leukemia [3_vs_6_mo_RNA-Seq]